Fetal undernutrition induces resistance artery remodeling and stiffness in male and female rats independent of hypertension
Entity
UAM. Departamento de FisiologíaPublisher
MDPIDate
2020-10-16Citation
10.3390/biomedicines8100424
Biomedicines 8.10 (2020): 424
ISSN
2227-9059DOI
10.3390/biomedicines8100424Funded by
This research was funded by Ministerio de Ciencia, Inovación y Universidades (Spain), grant number RTI2018-097504-B-I00Project
Gobierno de España. RTI2018-097504-B-I00Editor's Version
https://doi.org/10.3390/biomedicines8100424Subjects
fetal programming; hypertension; resistance arteries; metalloproteases; vascular mechanics; vascular remodeling; sexual dimorphism; MedicinaRights
© 2020 by the authorsAbstract
Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance
artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces
resistance artery remodeling and the relationship with hypertension. Sprague–Dawley dams were
fed ad libitum (Control) or with 50% of control intake between days 11 and 21 of gestation (maternal
undernutrition, MUN). In six-month-old male and female offspring we assessed blood pressure
(anesthetized and tail-cuff); mesenteric resistance artery (MRA) structure and mechanics (pressure
myography), cellular and internal elastic lamina (IEL) organization (confocal microscopy) and plasma
MMP-2 and MMP-9 activity (zymography). Systolic blood pressure (SBP, tail-cuff) and plasma
MMP activity were assessed in 18-month-old rats. At the age of six months MUN males exhibited
significantly higher blood pressure (anesthetized or tail-cuff) and plasma MMP-9 activity, while MUN
females did not exhibit significant differences, compared to sex-matched controls. MRA from
6-month-old MUN males and females showed a smaller diameter, reduced adventitial, smooth
muscle cell density and IEL fenestra area, and a leftward shift of stress-strain curves. At the age of
eighteen months SBP and MMP-9 activity were higher in both MUN males and females, compared to
sex-matched controls. These data suggest that fetal undernutrition induces MRA inward eutrophic
remodeling and stiffness in both sexes, independent of blood pressure level. Resistance artery
structural and mechanical alterations can participate in the development of hypertension in aged
females and may contribute to adverse cardiovascular events associated with low birth weight in
both sexes
Files in this item
Google Scholar:Gutiérrez-Arzapalo, Perla Y.
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Rodríguez-Rodríguez, Pilar
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Ramiro-Cortijo, David
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Gil-Ortega, Marta
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Somoza, Beatriz
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López de Pablo León, Ángel Luis
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González, María del Carmen
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Arribas Rodríguez, Silvia Magdalena
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