Chronodisruption: A poorly recognized feature of CKD
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
MDPI, Basel, SwitzerlandDate
2020-02-28Citation
10.3390/toxins12030151
Toxins 12.3 (2020):151
ISSN
2072-6651DOI
10.3390/toxins12030151Funded by
This work was funded by FIS CP14/00133, PI16/02057, PI18/01366, PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, National Institute of Health (2R01AI063331), ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet MS14/00133 to MDSN and ABS. IIS-Fundacion Jimenez Diaz Biobank, part of the Spanish Biobanks Platform (PT17/0015/0006). The APC was funded by PI19/00815Project
Gobierno de España. CP14/00133; Gobierno de España. PI16/02057; Gobierno de España. PI18/01366; Gobierno de España. PI19/00588; Gobierno de España. PI19/00815; Gobierno de España. DTS18/00032; Gobierno de España. RD016/0009; Comunidad de Madrid. B2017/BMD-3686/CIFRA2Editor's Version
http://doi.org/10.3390/toxins12030151Subjects
Chronodisruption; Chronodisruptor; Circadian rhythm; Internal clock; Chronic kidney disease; MedicinaRights
© 2020 The AuthorsAbstract
Multiple physiological variables change over time in a predictable and repetitive manner,
guided by molecular clocks that respond to external and internal clues and are coordinated by a
central clock. The kidney is the site of one of the most active peripheral clocks. Biological rhythms,
of which the best known are circadian rhythms, are required for normal physiology of the kidneys
and other organs. Chronodisruption refers to the chronic disruption of circadian rhythms leading
to disease. While there is evidence that circadian rhythms may be altered in kidney disease and
that altered circadian rhythms may accelerate chronic kidney disease (CKD) progression, there is no
comprehensive review on chronodisruption and chronodisruptors in CKD and its manifestations.
Indeed, the term chronodisruption has been rarely applied to CKD despite chronodisruptors being
potential therapeutic targets in CKD patients. We now discuss evidence for chronodisruption in CKD
and the impact of chronodisruption on CKD manifestations, identify potential chronodisruptors,
some of them uremic toxins, and their therapeutic implications, and discuss current unanswered questions on this topic
Files in this item
Google Scholar:Carriazo, Sol
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Ramos, Adrián M.
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Sánchez Niño, María Dolores
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Kanbay, Mehmet
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Ortiz Arduán, Alberto
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