GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
MDPI, Basel, SMwitzerlandDate
2020-03-30Citation
10.3390/jcm9040947
Journal of Clinical Medicine 9.4 (2020): 947
ISSN
2077-0383DOI
10.3390/jcm9040947Editor's Version
http://doi.org/10.3390/jcm9040947Subjects
Chronic kidney disease; Diabetic kidney disease; GLP-1; MedicinaRights
© 2020 The AuthorsAbstract
Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease (CKD)
and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major cause of morbidity
and mortality in diabetes. Despite advances in the nephroprotective treatment of T2DM, DKD remains
the most common complication, driving the need for renal replacement therapies (RRT) worldwide,
and its incidence is increasing. Until recently, prevention of DKD progression was based around strict
blood pressure (BP) control, using renin–angiotensin system blockers that simultaneously reduce BP
and proteinuria, adequate glycemic control and control of cardiovascular risk factors. Glucagon-like
peptide-1 receptor agonists (GLP-1RA) are a new class of anti-hyperglycemic drugs shown to improve
cardiovascular and renal events in DKD. In this regard, GLP-1RA o er the potential for adequate
glycemic control in multiple stages of DKD without an increased risk of hypoglycemia, preventing the onset of macroalbuminuria and slowing the decline of glomerular filtration rate (GFR) in diabetic patients, also bringing additional benefit in weight reduction, cardiovascular and other kidney outcomes. Results from ongoing trials are pending to assess the impact of GLP-1RA treatments on primary kidney endpoints in DKD
Files in this item
Google Scholar:Górriz, José Luis
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Soler, María José
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Navarro-González, Juan F.
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García-Carro, Clara
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Puchades, María Jesús
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D’Marco, Luis
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Martínez Castelao, Alberto
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Fernández-Fernández, Beatriz
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Ortiz Arduán, Alberto
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Górriz-Zambrano, Carmen
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Navarro-Pérez, Jorge
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Gorgojo-Martinez, Juan José
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