Alterations in respiratory function test three months after hospitalisation for covid-19 pneumonia: Value of determining nitric oxide diffusion
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
MDPI, Basel, SwitzerlandDate
2021-05-14Citation
10.3390/jcm10102119
Journal of Clinical Medicine 10.10 (2021): 2119
ISSN
2077-0383DOI
10.3390/jcm10102119Funded by
This research was funded by the Traslaciona Grant Program (code CT-850A-3 from the Xunta de Galicia (FEDER).Editor's Version
https://doi.org/10.3390/jcm10102119Subjects
COVID-19; Diffusion capacity; DL CO; DL NO; Pneumonia; Respiratory function tests; Sequelae; MedicinaRights
© 2021 The authorsAbstract
Three to four months after hospitalisation for COVID-19 pneumonia, the most frequently described alteration in respiratory function tests (RFTs) is decreased carbon monoxide transfer capacity (DLCO). Methods: This is a prospective cohort study that included patients hospitalised because of SARS-CoV-2 pneumonia, three months after their discharge. A clinical evaluation, analytical parameters, chest X-ray, six-minute walk test, spirometry and DLCO–DLNO analysis were performed. Demographic variables, comorbidities, and variables related to the severity of the admission were recorded. Results: Two hundred patients completed the study; 59.5% men, age 62 years, 15.5% admitted to the intensive care unit. The most frequent functional alteration, in 27% of patients, was in the DLCO–DLNO combination. This alteration was associated with age, male sex, degree of dyspnoea, poorer perception of health, and limited ability for physical effort. These patients also presented higher levels of D-Dimer and more residual radiological alterations. In 42% of the patients with diffusion alterations, only reduced DLNO was presented, along with lower D-Dimer levels and less capillary volume involvement. The severity of the process was associated with the reduction in DLCO–DLNO. Conclusions: The most sensitive RFT for the detection of the sequelae of COVID-19 pneumonia was the combined measurement of DLCO–DLNO and this factor was related to patient health status and their capacity for physical exertion. In 40% of these cases, there was only a reduction in DLNO, a finding that may indicate less pulmonary vascular involvement.
Files in this item
Google Scholar:Núñez-Fernández, Marta
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Ramos-Hernández, Cristina
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García Rio, Francisco
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Torres-Durán, María
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Nodar-Germiñas, Andrés
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Tilve-Gómez, Amara
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Rodríguez-Fernández, Paula
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Valverde-Pérez, Diana
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Ruano-Raviña, Alberto
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Fernández-Villar, Alberto
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