2-Hydroxybenzophenone as a Chemical Auxiliary for the Activation of Ketiminoesters for Highly Enantioselective Addition to Nitroalkenes under Bifunctional Catalysis
Entity
UAM. Departamento de Química OrgánicaPublisher
Wiley Online LibraryDate
2018-03-01Citation
10.1002/anie.201800435
Angewandte Chemie 57.19 (2018): 5350-5354
ISSN
1433-7851; 1521-3773DOI
10.1002/anie.201800435Project
Gobierno de España. CTQ2015-64561-R; Gobierno de España. CTQ2016- 76061-P; Gobierno de España. MDM-2014-0377Editor's Version
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201800435Subjects
QuímicaRights
©2018.The Author(s)Abstract
An organocatalytic system is presented for the Michael addition of monoactivated glycine ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group, which increases the acidity of the methylene hydrogen atoms and enhances the reactivity, thus allowing the synthesis of a large variety of a,g-diamino acid derivatives with excellent stereoselectivity
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Google Scholar:Guerrero-Corella, Andrea
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Esteban, Francisco
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Iniesta, Manuel
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Martín Somer, Ana
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Parra, Mario
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Díaz-Tendero Victoria, Sergio
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Fraile Carrasco, Alberto
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Alemán Lara, José Julián
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