Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19
Author
Nanwani-Nanwani, Kapil; López-Pérez, Lorenzo; Giménez-Esparza, Carola; Ruiz-Barranco, Inés; Carrillo, Elena; Arellano, María Soledad; Díaz-Díaz, Domingo; Hurtado, Beatriz; García-Muñoz, Andoni; Relucio, María Ángeles; Quintana Díaz, Manuel; Úrbez, María Rosario; Saravia, Andrés; Bonan, María Victoria; García Rio, Francisco; Testillano, María Luisa; Villar, Jesús; García de Lorenzo Mateos, Abelardo; Añón, José ManuelEntity
UAM. Departamento de CirugíaPublisher
Nature Publishing GroupDate
2022-05-13Citation
10.1038/s41598-022-11929-8
Scientific Reports 12 (2022): 7977
ISSN
2045-2322 (online)DOI
10.1038/s41598-022-11929-8Funded by
This study did not receive any funding or fnancial support. JMA and JV are funded by Grants from the Instituto de Salud Carlos III, Spain (CB06/06/1088, PI19/00141).Editor's Version
https://doi.org/10.1038/s41598-022-11929-8Subjects
Respiratory syndrome; Covid-19; Intensive care unit; Depression; Anxiety; Mechanical ventilation; MedicinaRights
© The Author(s) 2022Abstract
Coronavirus disease 19 (COVID-19) patients usually require long periods of mechanical ventilation and sedation, which added to steroid therapy, favours a predisposition to the development of delirium and subsequent mental health disorders, as well as physical and respiratory sequelae. The aim of this study was to determine the prevalence of post-intensive care syndrome (PICS) at 3 months after hospital discharge, in a cohort of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ambispective, observational study was conducted in three hospitals with intensive care unit (ICU) follow-up clinics. We studied adults who survived a critical illness due to SARS-CoV-2 infection requiring invasive mechanical ventilation. A physical (muscle strength and pulmonary function), functional [12-Item Short Form Health Survey (SF-12), and Barthel score], psychological [hospital anxiety and depression (HADS) and posttraumatic stress disorder symptom severity scales], and cognitive [Montreal cognitive assessment (MoCA) test] assessment were performed. A total of 186 patients were evaluated at 88 days (IQR 68–121) after hospital discharge. Mean age was 59 ± 12 years old, 126 (68%) patients were men, and median length of mechanical ventilation was 14 days (IQR 8–31). About 3 out of 4 patients (n = 139, 75%) met PICS criteria. Symptoms of cognitive and psychiatric disorders were found in 59 (32%) and 58 (31%) patients, respectively. Ninety-one (49%) patients had muscle weakness. Pulmonary function tests in patients with no respiratory comorbidities showed a normal pattern in 93 (50%) patients, and a restrictive disorder in 62 (33%) patients. Also, 69 patients (37%) were on sick leave, while 32 (17%) had resumed work at the time of assessment. In conclusion, survivors of critical illness due to SARS-CoV-2 infection requiring mechanical ventilation have a high prevalence of PICS. Physical domain is the most frequently damaged, followed by cognitive and psychiatric disorders. ICU follow-up clinics enable the assistance of this vulnerable population
Files in this item
Google Scholar:Nanwani-Nanwani, Kapil
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López-Pérez, Lorenzo
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Giménez-Esparza, Carola
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Ruiz-Barranco, Inés
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Carrillo, Elena
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Arellano, María Soledad
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Díaz-Díaz, Domingo
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Hurtado, Beatriz
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García-Muñoz, Andoni
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Relucio, María Ángeles
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Quintana Díaz, Manuel
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Úrbez, María Rosario
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Saravia, Andrés
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Bonan, María Victoria
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García Rio, Francisco
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Testillano, María Luisa
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Villar, Jesús
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García de Lorenzo Mateos, Abelardo
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Añón, José Manuel
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