Vitamin D, cellular senescence and chronic kidney diseases: what is missing in the equation?
Entity
UAM. Departamento de MedicinaPublisher
MDPIDate
2023-03-10Citation
10.3390/nu15061349
Nutrients 15.6 (2023): 1349
ISSN
2072-6643 (online)DOI
10.3390/nu15061349Funded by
This research was funded by grants from the Instituto de Salud Carlos III (ISCIII) and Fondos FEDER European Union (PI20/00140, PI19/00240, PI19/00815, and DTS20/00083). Red de Investigación Renal REDINREN: RD16/0009/0003 to M.R.-O. and RICORS2040; RD21/0005/0002 funded by European Union—NextGenerationEU, INNOREN cm (P2022/BMD-7221) of the Comunidad de Madrid, Sociedad Española de Nefrología. Innovation programme under the Marie Skłodowska-Curie grant of the European Union’s Horizon 2020 (IMProve-PD ID: 812699) to M.R.-OProject
Gobierno de España. PI20/00140; Gobierno de España. PI19/00240; Gobierno de España. PI19/00815; Gobierno de España. DTS20/00083Subjects
vitamin D; cellular senescence; biological aging; premature aging; chronic kidney diseases; MedicinaRights
© 2023 by the authorsAbstract
As life expectancy increases in many countries, the prevalence of age-related diseases also
rises. Among these conditions, chronic kidney disease is predicted to become the second cause of
death in some countries before the end of the century. An important problem with kidney diseases is
the lack of biomarkers to detect early damage or to predict the progression to renal failure. In addition,
current treatments only retard kidney disease progression, and better tools are needed. Preclinical
research has shown the involvement of the activation of cellular senescence-related mechanisms
in natural aging and kidney injury. Intensive research is searching for novel treatments for kidney
diseases as well as for anti-aging therapies. In this sense, many experimental shreds of evidence
support that treatment with vitamin D or its analogs can exert pleiotropic protective effects in kidney
injury. Moreover, vitamin D deficiency has been described in patients with kidney diseases. Here, we
review recent evidence about the relationship between vitamin D and kidney diseases, explaining the
underlying mechanisms of the effect of vitamin D actions, with particular attention to the modulation
of cellular senescence mechanisms
Files in this item
Google Scholar:Martinelli, Romina P.
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Rayego-Mateo, Sandra
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Alique, Matilde
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Márquez Expósito, Laura
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Tejedor-Santamaría, Lucía
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Ortiz Arduán, Alberto
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González Parra, Emilio José
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Ruiz Ortega, Marta
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