Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca2+ signaling in neuronal mitochondria
Entity
UAM. Departamento de Biología MolecularPublisher
WileyDate
2007-05-11Citation
10.1002/jnr.21299
Journal of Neuroscience Research 85.15 (2007): 3359-3366
ISSN
0360-4012 (print); 1097-4547 (online)DOI
10.1002/jnr.21299Funded by
Ministerio de Educación y Ciencia; Contract grant numbers: BFU2005-C02-01 and GEN2003-20235-C05-03/NAC; Contract grant sponsor: Instituto de Salud Carlos III del Ministerio de Sanidad; Contract grant numbers: PI042457; Contract grant sponsor: European Union; Contract grant numbers: LSHM-CT-2006-518153 (to J.S.); Contract grant sponsor: Fundación Ramón Areces (institutional grant to Centro de Biología Molecular Severo Ochoa)Editor's Version
https://doi.org/10.1002/jnr.21299Subjects
Aralar; Calcium; Mitochondria; Aspartate-Glutamate Carrier; N-Acetylaspartate; Biología y Biomedicina / BiologíaNote
"This is the peer reviewed version of the following article: Journal of Neuroscience Research 85.15 (2007): 3359-3366, which has been published in final form at https://doi.org/10.1002/jnr.21299. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions"Rights
© 2007 Wiley-Liss, Inc.Abstract
Aralar, the Ca2+-dependent mitochondrial aspartate-glutamate carrier expressed in brain and skeletal muscle, is a member of the malate-aspartate NADH shuttle. Disrupting the gene for aralar, SLC25a12, in mice has enabled the discovery of two new roles of this carrier. On the one hand, it is required for synthesis of brain aspartate and N-acetylaspartate, a neuron-born metabolite that supplies acetate for myelin lipid synthesis; and on the other, it is essential for the transmission of small Ca2+ signals to mitochondria via an increase in mitochondrial NADH
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Google Scholar:Satrustegui Gil Delgado, Jorgina
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Contreras Balsa, Laura
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Ramos, Milagros
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Marmol, Patricia
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Del Arco, Araceli
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Saheki, Takeyori
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Pardo Merino, Beatriz
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