Phthalocyanine-DNA origami complexes with enhanced stability and optical properties
Entity
UAM. Departamento de Química OrgánicaPublisher
Royal Society of ChemistryDate
2020-05-26Citation
10.1039/d0cc01916j
Chemical Communications 56.53 (2020): 7341-7344
ISSN
1359-7345 (print); 1364-548X (online)DOI
10.1039/d0cc01916jFunded by
We acknowledge the Academy of Finland (286845, 308578), the Marie Sklodowska-Curie grant (794536), Emil Aaltonen Foundation, The Swedish Cultural Foundation, Jane and Aatos Erkko Foundation, Sigrid Juse´lius Foundation and the Spanish MINECO (CTQ2017-85393-P and CTQ-2017-89539-P, PCIN-2017-042/EuroNanoMed2017-191, TEMPEAT) with European Union FEDER funds. The work was carried out under the Academy of Finland’s Centre of Excellence Programme (2014–2019). IMDEA Nanociencia acknowledges support from the ‘‘Severo Ochoa’’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV2016-0686)Project
Gobierno de España. CTQ2017-85393-P; Gobierno de España. CTQ-2017-89539-P; Gobierno de España. PCIN-2017- 042/EuroNanoMed2017-191; Gobierno de España. SEV2016-0686; info:eu-repo/grantAgreement/EC/H2020/794536Editor's Version
https://doi.org/-10.1039/d0cc01916jSubjects
DNA; Phthalocyanine; Photodynamic therapy; DNA origami (DO); Optical communication; QuímicaRights
This journal is © The Royal Society of Chemistry 2020Abstract
In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy
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Google Scholar:Shaukat, Ahmed
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Anaya-Plaza, Eduardo
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Julin, Sofia
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Linko, Veikko
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Torres Cebada, Tomás
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Escosura Navazo, Andrés de la
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Kostiainen, Mauri A.
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