Sustainable extraction techniques for obtaining antioxidant and anti-inflammatory compounds from the lamiaceae and asteraceae species
Publisher
MDPIDate
2021-09-01Citation
10.3390/foods10092067
Foods 10.9 (2021): 2067
ISSN
2304-8158 (online)DOI
10.3390/foods10092067Funded by
Funding: Authors thanks to the Spanish Government (Project: PID2019-110183RBC22/AEI/10.13039/501100011033) and Comunidad Autónoma de Madrid (ALIBIRD2020-CM (S2018/BAA-4343)) for financial support.Project
Gobierno de España. PID2019-110183RBC22; Comunidad de Madrid. S2018/ALIBIRD2020-CMEditor's Version
https://doi.org/10.3390/foods10092067Subjects
Achillea millefolium; Anti-inflammatory activity; Antioxidant activity; Origanum majorana; Phenolic composition; Sustainable extraction; Ciencia y Tecnología de AlimentosRights
© 2021 by the authors. Licensee MDPI, Basel, SwitzerlandAbstract
Melissa officinalis L. and Origanum majorana L., within Lamiaceae family, and Calendula officinalis L. and Achillea millefolium L., within the Asteraceae, have been considered a good source of bioactive ingredients with health benefits. In this study, the supercritical fluid extraction (SFE) using pure CO2, and the ultrasound assisted extraction (UAE) were proposed as green techniques to obtain plant-based extracts with potential antioxidant and anti-inflammatory activities. Higher values of total phenolic content and antioxidant activity were achieved in UAE ethanol:water (50:50, v/v) extracts. Meanwhile, UAE pure ethanol extracts showed greater anti-inflammatory activity. RP-HPLC-PAD-ESI-QTOF-MS/MS analysis showed a vast number of phenolic compounds in the ex-tracts, including unreported ones. O. majorana ethanol:water extract presented the highest content of phenolics and antioxidant activity; among its composition, both rosmarinic acid and luteolin glu-coside derivatives were abundant. The pure ethanol extract of A. millefolium resulted in an important content of caffeoylquinic acid derivatives, luteolin-7-O-glucoside and flavonoid aglycones, which could be related to the remarkable inhibition of TNF-α, IL-1β and IL-6 cytokines. Besides, borneol and camphor, found in the volatile fraction of A. millefolium, could contributed to this latter activity. Thus, this study points out that O. majorana and A. millefolium are considered a promising source of bioactive ingredients with potential use in health promotion
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Google Scholar:Villalva, Marisol
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Santoyo, Susana
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Salas-Pérez, Lilia
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Siles-Sánchez, María de las Nieves
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García-Risco, Mónica Rodríguez
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Fornari, Tiziana
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Reglero, Guillermo
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Jaime, Laura
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