Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS<inf>2</inf> for enhanced melatonin quantification
Entity
UAM. Departamento de Química Analítica y Análisis InstrumentalPublisher
NatureDate
2023-12Citation
10.1038/s41598-023-37401-9
Scientific Reports 13 (2023): 10378
ISSN
1476-4687DOI
10.1038/s41598-023-37401-9Funded by
The authors acknowledge financial support from projects PID2020-113142RB-C21 and PID2020-113142RB-C22 and TED2021-129416A-I00 funded by MCIN/AEI/https://doi.org/10.13039/501100011033 and P2018/NMT 4349 (TRANSNANOAVANSENS-CM) funded by the Comunidad Autónoma de MadridProject
Gobierno de España. PID2020-113142RB-C21; Gobierno de España. PID2020-113142RB-C22; Gobierno de España. TED2021-129416A-I00; Comunidad de Madrid. P2018/NMT-4349Editor's Version
https://doi.org/10.1038/s41598-023-37401-9Subjects
Electrochemical Techniques; humans; limit of detection; melatonin; molybdenum; QuímicaRights
© The Author(s) 2023Abstract
We present the development of an electrochemical sensor towards melatonin determination based on the synergistic effect between MoS2 nanosheets and cucurbit[8]uril. For the sensor construction cucurbit[8]uril suspensions were prepared in water, and MoS2 nanosheets were obtained by liquid exfoliation in ethanol:water. The sensing platform was topographically characterized by Atomic Force Microscopy. Electrochemical Impedance Spectroscopy experiments allowed us to study the charge transfer process during melatonin oxidation. Moreover, stoichiometry of the resulting complex has also been determined. After the optimization of the sensor construction and the experimental variables involved in the Differential Pulse Voltammetric response of melatonin, detection limit of 3.80 × 10−7 M, relative errors minor than 3.8% and relative standard deviation lower than 4.4% were obtained. The proposed sensor has been successfully applied to melatonin determination in pharmaceutical and biological samples as human urine and serum, with very good recoveries ranging from 90 to 102%
Files in this item
Google Scholar:Martínez-Moro, Rut
-
del Pozo, María
-
Vázquez, Luis
-
Martín-Gago, José A.
-
Petit Domínguez, María Dolores
-
Casero, Elena
-
Quintana, Carmen
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.