Hypertensive effects of the iv administration of picomoles of ouabain
Entidad
UAM. Departamento de FarmacologíaEditor
Associação Brasileira de Divulgação CientíficaFecha de edición
2011-09-01Cita
10.1590/S0100-879X2011007500103
Brazilian Journal of Medical and Biological Research 44.9 ( (2011): 933-938
ISSN
0100-879XDOI
10.1590/S0100-879X2011007500103Financiado por
Research supported by CNPq, CAPES, FAPES/ FUNCITEC (#SAF2009 02376) and MCIIN (#SAF2009 02376) and Banco Santader.Versión del editor
http://dx.doi.org/10.1590/S0100-879X2011007500103Materias
Hypertension; Ouabain; Renin-angiotensin system; Vascular reactivity; Farmacia; MedicinaDerechos
© A.S. Padilha et al.Resumen
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals
and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension
models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible
association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for
this association is that ouabain binds to the α-subunit of the Na+ pump, inhibiting its activity. Inhibition of this pump increases
intracellular Na+, which reduces the activity of the sarcolemmal Na+/Ca2+ exchanger and thereby reduces Ca2+ extrusion.
Consequently, intracellular Ca2+ increases and is taken up by the sarcoplasmic reticulum, which, upon activation, releases
more calcium and increases the vascular smooth muscle tone. In fact, acute treatment with ouabain enhances the vascular
reactivity to vasopressor agents, increases the release of norepinephrine from the perivascular adrenergic nerve endings and
promotes increases in the activity of endothelial angiotensin-converting enzyme and the local synthesis of angiotensin II in the
tail vascular bed. Additionally, the hypertension induced by ouabain has been associated with central mechanisms that increase
sympathetic tone, subsequent to the activation of the cerebral renin-angiotensin system. Thus, the association with peripheral
mechanisms and central mechanisms, mainly involving the renin-angiotensin system, may contribute to the acute effects of
ouabain-induced elevation of arterial blood pressure
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Google Scholar:Padilha, Alessandra Simão
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Salaices Sánchez, Mercedes
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Vassallo, Dalton Valentim
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Batista, Priscila Rossi
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Siman, Fabiana Dayse Magalhães
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