Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
Author
Herrera, Mercedes A.; Herrera, Alberto F.; Domínguez Muñoz, Gemma; Silva, Javier M.; García, Vanesa Quiroga; García, José Miguel Jurado; Gómez, Irene; Soldevilla, Beatriz; Muñoz, Concepción Morales; Provencio Pulla, Mariano; Campos-Martín, Yolanda; Garcia de Herreros, Antonio; Casal, Ignacio; Bonilla, Félix; Peña, CristinaEntity
UAM. Departamento de MedicinaPublisher
Japanese Cancer AssociationDate
2013-04-01Citation
10.1111/cas.12096
Cancer Science 104.4 (2013):437-444
ISSN
1347-9032 (print); 1349-7006 (online)DOI
10.1111/cas.12096Funded by
This work has been supported by Fundación Científica AECC, SAF2010-20750, S2010 ⁄BMD-2344, RTICC-RD06 ⁄ 0020 ⁄ 0020, PI12 ⁄ 02037 and Fundación Banco Santander. A.G.H. laboratory was supported by RD06 ⁄ 0020 ⁄ 0040. C.P. is the recipient of a Miguel Servet Contract from the Instituto de Salud Carlos III (CP09 ⁄ 00294) and V.G. is the recipient of a Fundación Científica AECC fellowshipProject
Comunidad de Madrid. S2010/BMD-2344/COLOMICS2Editor's Version
http://dx.doi.org/doi: 10.1111/cas.12096Subjects
Tumor epithelial cells; M2; Colorectal cancer; Patients; MedicinaRights
© 2013 Japanese Cancer AssociationAbstract
Tumor epithelial cells within a tumor coexist with a complex microenvironment
in which a variety of interactions between its various
components determine the behavior of the primary tumors. Cancer-
associated fibroblasts (CAF) and M2 macrophages, characterized
by high expression of different markers, including a-SMA,
FSP1 and FAP, or CD163 and DCSIGN, respectively, are involved in
the malignancy of different tumors. In the present study, expression
of the above markers in CAF and M2 macrophages was analyzed
using RT-PCR and immunohistochemistry in the normal
mucosa and tumor tissue from a cohort of 289 colorectal cancer
patients. Expression of CAF and M2 markers is associated with the
clinical outcome of colorectal cancer patients. Moreover, the combination
of CAF and M2 markers identifies three groups of patients
with clear differences in the progression of the disease. This combined
variable could be a decisive factor in the survival of
advanced-stage patients. Taken together, these analyses demonstrate
the prognostic involvement of interrelationships between
DCSIGN, CD163, a-SMA, FSP1 and FAP markers in the survival of
colon cancer patients.
Files in this item
Google Scholar:Herrera, Mercedes A.
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Herrera, Alberto F.
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Domínguez Muñoz, Gemma
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Silva, Javier M.
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García, Vanesa Quiroga
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García, José Miguel Jurado
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Gómez, Irene
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Soldevilla, Beatriz
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Muñoz, Concepción Morales
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Provencio Pulla, Mariano
-
Campos-Martín, Yolanda
-
Garcia de Herreros, Antonio
-
Casal, Ignacio
-
Bonilla, Félix
-
Peña, Cristina
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