Toxic effects of mercury, lead and gadolinium on vascular reactivity
Entidad
UAM. Departamento de FarmacologíaEditor
Associação Brasileira de Divulgação CientíficaFecha de edición
2011-09-01Cita
10.1590/S0100-879X2011007500098
Brazilian Journal of Medical and Biological Research 44.9 ( (2011): 939-946
ISSN
0100-879X (print); 1414-431X (online)DOI
10.1590/S0100-879X2011007500098Financiado por
Research supported by CAPES and CNPq/FAPES/ FUNCITEC (#39767531/07), Brazil, and MCINN (#SAF 2009-07201) and ISCIII (Red RECAVA, #RD06/0014/0011), SpainVersión del editor
http://dx.doi.org/0.1590/S0100-879X2011007500098Materias
Gadolinium; Heavy metal toxicity; Lead; Mercury; Vascular reactivity; MedicinaResumen
Heavy metals have been used in a wide variety of human activities that have significantly increased both professional and
environmental exposure. Unfortunately, disasters have highlighted the toxic effects of metals on different organs and systems.
Over the last 50 years, the adverse effects of chronic lead, mercury and gadolinium exposure have been underscored. Mercury
and lead induce hypertension in humans and animals, affecting endothelial function in addition to their other effects. Increased
cardiovascular risk after exposure to metals has been reported, but the underlying mechanisms, mainly for short periods of
time and at low concentrations, have not been well explored. The presence of other metals such as gadolinium has raised
concerns about contrast-induced nephropathy and, interestingly, despite this negative action, gadolinium has not been defined
as a toxic agent. The main actions of these metals, demonstrated in animal and human studies, are an increase of free radical
production and oxidative stress and stimulation of angiotensin I-converting enzyme activity, among others. Increased vascular
reactivity, highlighted in the present review, resulting from these actions might be an important mechanism underlying increased
cardiovascular risk. Finally, the results described in this review suggest that mercury, lead and gadolinium, even at low doses
or concentrations, affect vascular reactivity. Acting via the endothelium, by continuous exposure followed by their absorption, they
can increase the production of free radicals and of angiotensin II, representing a hazard for cardiovascular function. In addition,
the actual reference values, considered to pose no risk, need to be reduced
Lista de ficheros
Google Scholar:Vassallo, Dalton Valentim
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Simões, Maylla Ronacher
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Furieri, Lorena Barros
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Fioresi, Mirian
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Fiorim, Jonaina
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Almeida, Edna Aparecida Silveira
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Angeli, Jhuli Keli
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Wiggers, Giulia Alessandra
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Peçanha, Franck MacIel
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Salaices Sánchez, Mercedes
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