TWIST1 is expressed in colorectal carcinomas and predicts patient survival
Entity
UAM. Departamento de MedicinaPublisher
Public Library of ScienceDate
2011-04-04Citation
10.1371/journal.pone.0018023
Plos One 6.3 (2011): e18023
ISSN
1932-6203 (online)DOI
10.1371/journal.pone.0018023Funded by
This study was supported by grants from: Foundation AECC, S-GEN/0266/2006, RD06/0020/0020, SAF2010-20750 and RD06/0020/0040. JMG is supported by ISCIII-CP08/00217Subjects
Colorectal Neoplasms; Gene Expression Regulation; Kaplan-Meier Estimate; Lymphatic Metastasis; Nuclear Proteins; MedicinaRights
© 2011 Gomez et al.Abstract
TWIST1 is a transcription factor that belongs to the family of basic helix-loop-helix proteins involved in epithelial-to-mesenchymal transition and invasion processes. The TWIST1 protein possesses oncogenic, drug-resistant, angiogenic and invasive properties, and has been related with several human tumors and other pathologies. Colorectal cancer is one of the tumors in which TWIST1 is over-expressed, but its involvement in the clinical outcome of the disease is still unclear. We tested, by RT-PCR, the expression levels of TWIST1 in normal and tumor paired-sample tissues from a series of 151 colorectal cancer patients, in order to investigate its prognostic value as a tumor marker. TWIST1 expression was restricted to tumor tissues (86.1%) and correlated with lymph node metastasis (LNM). Adjusted analysis showed that the expression levels of TWIST1 correlated with overall survival (OS) and disease-free survival (DFS). Importantly, TWIST1 expression levels predicted OS specifically at stages I and II. Moreover, patients with stage II tumors and high TWIST1 levels showed even shorter survival than patients with stage III tumors. These results suggest that TWIST1 expression levels could be a tumor indicator in stage II patients and help select patients at greater risk of poor prognosis who might benefit from adjuvant chemotherapy
Files in this item
Google Scholar:Gómez, Irene
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Peña, Cristina
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Herrera, Mercedes A.
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Muñoz, Concepción
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Larriba, María Jesús
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García, Vanesa
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Domínguez Muñoz, Gemma
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Silva, Javier M.
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Rodríguez, Rufo
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Garcia de Herreros, Antonio
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Bonilla, Félix
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García, José Miguel Jurado
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