Oxidative stress enhances neurodegeneration markers induced by herpes simplex virus type 1 infection in human neuroblastoma cells
Entidad
UAM. Departamento de Biología MolecularEditor
Public Library of ScienceFecha de edición
2013-10-04Cita
10.1371/journal.pone.0075842
Plos One 8.10 (2013): e75842
ISSN
1932-6203 (online)DOI
10.1371/journal.pone.0075842Financiado por
This work was supported by grants from the Ministerio de Economia y Competitividad (SAF2010-15558; URL: http://www.mineco.gob.es/portal/site/mineco) and Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED (PI2010/09-8; URL: http://www.ciberned.es)Materias
Alzheimer Disease; Cell Line, Tumor; Herpesvirus 1; Neuroblastoma; Oxidative Stress; Biología y Biomedicina / BiologíaDerechos
© 2013 Santana et al.Resumen
Mounting evidence suggests that Herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of Alzheimer's disease (AD). Previous work from our laboratory has shown HSV-1 infection to induce the most important pathological hallmarks of AD brains. Oxidative damage is one of the earliest events of AD and is thought to play a crucial role in the onset and development of the disease. Indeed, many studies show the biomarkers of oxidative stress to be elevated in AD brains. In the present work the combined effects of HSV-1 infection and oxidative stress on Aβ levels and autophagy (neurodegeneration markers characteristic of AD) were investigated. Oxidative stress significantly potentiated the accumulation of intracellular Aβ mediated by HSV-1 infection, and further inhibited its secretion to the extracellular medium. It also triggered the accumulation of autophagic compartments without increasing the degradation of long-lived proteins, and enhanced the inhibition of the autophagic flux induced by HSV-1. These effects of oxidative stress were not due to enhanced virus replication. Together, these results suggest that HSV-1 infection and oxidative damage interact to promote the neurodegeneration events seen in AD
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Google Scholar:Santana, Soraya
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Sastre, Isabel
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Recuero, Maria
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Bullido Gómez-Heras, María Jesús
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Aldudo Soto, Jesús
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