Neural coding of tactile decisions in the human prefrontal cortex
Entity
UAM. Departamento de Psicología Biológica y de la SaludPublisher
Society for NeuroscienceDate
2006-11-29Citation
10.1523/JNEUROSCI.4275-06.2006
The Journal of Neuroscience 26.48 (2006): 12596–12601
ISSN
0270-6474 (print); 1529-2401 (online)DOI
10.1523/JNEUROSCI.4275-06.2006Editor's Version
http://dx.doi.org/10.1523/JNEUROSCI.4275-06.2006Subjects
Tactile decision; Tactile discrimination; Weber fraction; Somatosensory cortex; Dorsolateral prefrontal cortex; Functional magnetic resonance imaging; Medicina; PsicologíaRights
© 2006 Society for NeuroscienceEsta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional.
Abstract
The neural processes underlying tactile decisions in thehumanbrain remain elusive.Weaddressed this question in a functional magnetic resonance imaging study using a somatosensory discrimination task, requiring participants to compare the frequency of two successive tactile stimuli. Tactile stimuli per se engaged somatosensory, parietal, and frontal cortical regions. Using a statistical model that accounted
for the relative difference in frequencies (i.e., Weber fraction) and discrimination accuracy (i.e., correct or incorrect), we show that trial-by-trial relative frequency difference is represented linearly by activity changes in the left dorsolateral prefrontal cortex
(DLPFC), the dorsal anterior cingulate cortex, and bilateral anterior insular cortices. However, a circumscribed region within the left DLPFC showed a different response pattern expressed as activity changes that were monotonically related to relative stimulation difference only for correct but not for incorrect trials. Our findings suggest that activity in the left DLPFC encodes stimulus representations that underlie veridical tactile decisions in humans.
Files in this item
Google Scholar:Pleger, Burkhard
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Ruff, Christian C.
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Blankenburg, Felix
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Bestmann, Sven
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Wiech, Katja
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Stephan, Klaas E.
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Capilla, Almudena
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Friston, Karl J.
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Dolan, Raymond J.
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