Giant bilateral renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and rapamycin
Entity
UAM. Departamento de MedicinaPublisher
Hindawi Publishing CorporationDate
2011-11-23Citation
10.1100/2011/263137
Scientific World Journal 11 (2011): 2115-2123
ISSN
2356-6140 (print); 1537-744X (online)DOI
10.1100/2011/263137Funded by
This work has been supported in part by grants from the Instituto de Salud Carlos III from Ministerio de Ciencia e Innovacion (EC08/00236) and Programa Intensi ´ ficacion Actividad Investigadora (IdiPAZ and ´ Agencia La´ın-Entralgo/CM) to R. PecesProject
Gobierno de España. EC08/00236Editor's Version
http://dx.doi.org/10.1100/2011/263137Subjects
Angiomyolipomas; Lymphangioleiomyomatosis; mTOR; Nephrectomy; Pregnancy; Tuberous sclerosis complex; MedicinaRights
© 2011 Ramón Peces et al.Abstract
We report the case of a 25-year-old woman who presented with abdominal and flank pain with
two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary
LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates
that in women with TSC rapid growth from renal AMLs and development of LAM may occur
with successive pregnancies. It also stresses the potential for preservation of renal function
despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose
rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered
as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs
Files in this item
Google Scholar:Peces, Ramón
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Cuesta-López, Emilio
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Peces, Carlos
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Selgas Gutiérrez, Rafael
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