ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
Author
Vargas, Teodoro; Moreno-Rubio, Juan; Herranz Barrera, Jesús; Cejas, Paloma; Molina, Susana; González-Vallinas, Margarita; Mendiola, Marta; Burgos, Emilio; Aguayo, Cristina; Custodio, Ana B.; Machado, Isidro; Ramos, David; Gironella, Meritxell; Espinosa-Salinas, Isabel; Ramos, Ricardo; Martín-Hernández, Roberto; Risueño, Alberto; Las Rivas, Javier de; Reglero Rada, Guillermo J.; Yaya, Ricardo; Fernández-Martos, Carlos; Aparicio, Jorge; Maurel, Joan; Feliú Batlle, Jaime; Ramírez de Molina, AnaEntity
UAM. Departamento de Bioquímica; UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ); UAM. Departamento de Química Física AplicadaPublisher
Impact JournalsDate
2015-02-06Citation
10.18632/oncotarget.3130
Oncotarget 6.9 (2015): 7348-7363
ISSN
1949-2553DOI
10.18632/oncotarget.3130Funded by
This work was supported by Ministerio de Ciencia e Innovación del Gobierno de España (Plan Nacional I + D + i AGL2013–48943-C2–2-R and IPT-2011–1248-060000), Comunidad de Madrid (P2013/ABI-2728. ALIBIRDCM) and European Union Structural Funds. CIBEREHD is funded by the Instituto de Salud Carlos III. This is a collaborative study between the Molecular Oncology Unit of The Institute of Advanced Studies of Madrid IMDEA Food and the Grupo Español Multidisciplinar en Cáncer Digestivo (GEMCAD)Project
Gobierno de España. AGL2013–48943-C2–2-R; Gobierno de España. PT-2011–1248-060000; Comunidad de Madrid. 2013/ABI-2728/ALIBIRDCMEditor's Version
http://dx.doi.org/10.18632/oncotarget.3130Subjects
Colon cancer; Lipid metabolism; Biomarker; Prognosis; MedicinaRights
© 2015 Impact JournalsAbstract
Lipid metabolism plays an essential role in carcinogenesis due to the requirements
of tumoral cells to sustain increased structural, energetic and biosynthetic precursor
demands for cell proliferation. We investigated the association between expression
of lipid metabolism-related genes and clinical outcome in intermediate-stage colon
cancer patients with the aim of identifying a metabolic profile associated with greater
malignancy and increased risk of relapse. Expression profile of 70 lipid metabolismrelated
genes was determined in 77 patients with stage II colon cancer. Cox regression
analyses using c-index methodology was applied to identify a metabolic-related
signature associated to prognosis. The metabolic signature was further confirmed in
two independent validation sets of 120 patients and additionally, in a group of 264
patients from a public database. The combined analysis of these 4 genes, ABCA1,
ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to
accurately stratify stage II colon cancer patients with 5-fold higher risk of relapse with
strong statistical power in the four independent groups of patients. The identification
of a group of 4 genes that predict survival in intermediate-stage colon cancer patients
allows delineation of a high-risk group that may benefit from adjuvant therapy, and
avoids the toxic and unnecessary chemotherapy in patients classified as low-risk group
Files in this item
Google Scholar:Vargas, Teodoro
-
Moreno-Rubio, Juan
-
Herranz Barrera, Jesús
-
Cejas, Paloma
-
Molina, Susana
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González-Vallinas, Margarita
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Mendiola, Marta
-
Burgos, Emilio
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Aguayo, Cristina
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Custodio, Ana B.
-
Machado, Isidro
-
Ramos, David
-
Gironella, Meritxell
-
Espinosa-Salinas, Isabel
-
Ramos, Ricardo
-
Martín-Hernández, Roberto
-
Risueño, Alberto
-
Las Rivas, Javier de
-
Reglero Rada, Guillermo J.
-
Yaya, Ricardo
-
Fernández-Martos, Carlos
-
Aparicio, Jorge
-
Maurel, Joan
-
Feliú Batlle, Jaime
-
Ramírez de Molina, Ana
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