Galactomannan downregulates the inflammation responses in human macrophages via NF κ B2/p100
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
Hindawi Publishing CorporationDate
2015-01-01Citation
10.1155/2015/942517
Mediators of Inflammation 2015 (2015): ID 942517
ISSN
0962-9351DOI
10.1155/2015/942517Funded by
They would also like to acknowledge the Fondo de Investigación Sanitaria grant awarded to ELCEditor's Version
http://dx.doi.org/10.1155/2015/942517Subjects
Galactomannan; Cells; Modulator of inflammatory; MedicinaRights
© 2015 Víıctor Toledano et al.Abstract
We show that galactomannan, a polysaccharide consisting of amannose backbone with galactose side groups present on the cell wall
of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The
nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NF𝜅B2)/p100 was overexpressed after galactomannan challenge.
Knocking down NF𝜅B2/p100 using small interfering RNA (siRNA) indicated that NF𝜅B2/p100 expression is a crucial factor in
the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of
inflammatory response in clinical situations where refractory state is required.
Files in this item
Google Scholar:Toledano, Víctor
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Hernández-Jiménez, Enrique
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Cubillos-Zapata, Carolina
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Flandez, Marta
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Álvarez, Enrique
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Varela-Serrano, Aníbal
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Cantero Cid, Ramón
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Valles, Gema
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García Rio, Francisco
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López-Collazo, Eduardo
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