Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
T helper 17/regulatory t cell balance and experimental models of peritoneal dialysis-induced damage
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD); Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ); Instituto de Investigación del Hospital de La Princesa (IP)Publisher
Hindawi Publishing CorporationDate
2015-01-01Citation
10.1155/2015/416480
BioMed Research International 2015 (2015): Article ID 416480
ISSN
2314-6133; 2314-6141 (online)DOI
10.1155/2015/416480Funded by
This work was supported in part by grants from Ministerio de EconomIa y competitividad SAF2010-21249 to Manuel López-Cabrera, Comunidad Autónoma de Madrid 2010- BMD2321 (FIBROTEAM) to Manuel López Cabrera, and Fondo de Investigaciones Santitarias RETICS 06/0016 and PI 09/0064 to Rafael Selgas and FIS 12/01175 to Abelardo Aguilera Peralta. Georgios Liappas is fully supported from European Union, Seventh Framework Program “EuTRiPD,” under Grant Agreement PITN-GA-2011-287813.Project
Gobierno de España. SAF2010-21249; Comunidad de Madrid. 2010-BMD2321/FIBROTEAM; info:eu-repo/grantAgreement/EC/FP7/287813Editor's Version
http://dx.doi.org/10.1155/2015/416480Subjects
Fibrosis; Peritoneal damage; Th17/Treg balance; Regulatory T; MedicinaRights
© 2015 Georgios Liappas et al.Abstract
Fibrosis is a general complication in many diseases. It is the main complication during peritoneal dialysis (PD) treatment, a therapy
for renal failure disease. Local inflammation and mesothelial to mesenchymal transition (MMT) are well known key phenomena
in peritoneal damage during PD. New data suggest that, in the peritoneal cavity, inflammatory changes may be regulated at least in
part by a delicate balance between T helper 17 and regulatory T cells. This paper briefly reviews the implication of the Th17/Tregaxis
in fibrotic diseases. Moreover, it compares current evidences described in PD animal experimental models, indicating a loss
of Th17/Treg balance (Th17 predominance) leading to peritoneal damage during PD. In addition, considering the new clinical
and animal experimental data, new therapeutic strategies to reduce the Th17 response and increase the regulatory T response are
proposed.Thus, future goals should be to develop newclinical biomarkers to reverse this immunemisbalance and reduce peritoneal
fibrosis in PD.
Files in this item
Google Scholar:Liappas, Georgios
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Gónzalez-Mateo, Guadalupe Tirma
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Majano Rodríguez, Pedro Lorenzo
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Sánchez-Tomero, José Antonio
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Ruiz Ortega, Marta
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Rodrigues Díez, Raquel
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Martín, Pilar
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Sánchez-Díaz, Raquel
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Selgas, Rafael
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López-Cabrera, Manuel
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Aguilera Peralta, Abelardo
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