dc.contributor.author | López-Mejías, Raquel | |
dc.contributor.author | Corrales, Alfonso | |
dc.contributor.author | Vicente, Esther | |
dc.contributor.author | Robustillo-Villarino, Montserrat | |
dc.contributor.author | González-Juanatey, Carlos | |
dc.contributor.author | Llorca, Javier | |
dc.contributor.author | Genre, Fernanda | |
dc.contributor.author | Remuzgo-Martínez, Sara | |
dc.contributor.author | Dierssen-Sotos, Trinidad | |
dc.contributor.author | Miranda-Filloy, José Alberto | |
dc.contributor.author | Ramírez Huaranga, Marco A. | |
dc.contributor.author | Pina, Trinitario | |
dc.contributor.author | Blanco, Ricardo | |
dc.contributor.author | Alegre-Sancho, Juan J. | |
dc.contributor.author | Raya, Enrique | |
dc.contributor.author | Mijares, Verónica | |
dc.contributor.author | Ubilla, Begoña | |
dc.contributor.author | Ferraz-Amaro, Iván | |
dc.contributor.author | Gómez-Vaquero, Carmen | |
dc.contributor.author | Balsa Criado, Alejandro | |
dc.contributor.author | López-Longo, Francisco J. | |
dc.contributor.author | Carreira, Patricia | |
dc.contributor.author | González-Álvaro, Isidoro | |
dc.contributor.author | Ocejo-Vinyals, J. Gonzalo | |
dc.contributor.author | Rodríguez-Rodríguez, Luis | |
dc.contributor.author | Fernández-Gutiérrez, Benjamín | |
dc.contributor.author | Castañeda Sanz, Santos | |
dc.contributor.author | Martín, Javier | |
dc.contributor.author | González-Gay, Miguel A. | |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | es_ES |
dc.date.accessioned | 2017-07-18T13:08:11Z | |
dc.date.available | 2017-07-18T13:08:11Z | |
dc.date.issued | 2017-01-06 | |
dc.identifier.citation | Scientific Reports 7 (2017): 40303 | en_US |
dc.identifier.issn | 2045-2323 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/679055 | |
dc.description.abstract | A genetic component influences the development of atherosclerosis in the general population and
also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in
the general population are not always involved in the development of cardiovascular disease (CVD) in
RA. Accordingly, a study in North-American RA patients did not show the association reported in the
general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA,
HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-
COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD
in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of
subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may
influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical
atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid
intima media thickness and presence/absence of carotid plaques). No statistically significant differences
were found when each polymorphism was assessed according to the presence/absence of cardiovascular
events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do
not show an association between these 15 polymorphisms and atherosclerosis in RA | en_US |
dc.description.sponsorship | This study was supported by European Union FEDER funds and “Fondo de Investigación
Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060 and PI15/00525) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). It was also partially supported
by RETICS Programs RD12/0009 (RIER) from ‘Instituto de Salud Carlos III’ (ISCIII,
Health Ministry, Spain), and in part by grants from the European IMI BTCure Program.
RL-M and BU are supported by funds from the RETICS Program (RIER)
(RD12/0009/0013). FG is a recipient of a Sara Borrell postdoctoral fellowship from the “Instituto Carlos III de Salud” at the Spanish Ministry of Health (Spain) (CD15/00095) | en_US |
dc.format.extent | 6 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.rights | © The Author(s) 2017 | es_ES |
dc.subject.other | Atherosclerosis | en_US |
dc.subject.other | Rheumatoid arthritis | en_US |
dc.subject.other | Development of cardiovascular disease | en_US |
dc.subject.other | Polymorphisms | en_US |
dc.title | Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/srep40303 | es_ES |
dc.identifier.doi | 10.1038/srep40303 | es_ES |
dc.identifier.publicationfirstpage | 40303-1 | es_ES |
dc.identifier.publicationissue | 7 | es_ES |
dc.identifier.publicationlastpage | 40303-6 | es_ES |
dc.relation.projectID | Gobierno de España. PI06/0024 | es_ES |
dc.relation.projectID | Gobierno de España. PS09/00748 | es_ES |
dc.relation.projectID | Gobierno de España. PI12/00060 | es_ES |
dc.relation.projectID | Gobierno de España. PI15/00525 | es_ES |
dc.relation.projectID | Gobierno de España. CD15/00095 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | |