New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis
Entity
UAM. Departamento de FarmacologíaPublisher
NatureDate
2016-09-27Citation
10.1038/tpj.2016.64
Pharmacogenomics Journal 18 (2018): 70-75
ISSN
1470-269X (print); 1473-1150 (online)DOI
10.1038/tpj.2016.64Funded by
This study was supported by Instituto de Salud Carlos III (FIS PI10/01740), Fundación Teófilo Hernando, and AbbVie. RPP has a grant from Universidad Autónoma de Madrid (FPI program 2013)Project
Gobierno de España. PI10/01740Editor's Version
http://dx.doi.org/10.1038/tpj.2016.64Subjects
anti-TNF drugs; psoriasis; Farmacia; MedicinaRights
© 2016 Macmillan Publishers Limited, part of Springer NatureAbstract
Anti-tumor necrosis factor (anti-TNF) drugs are effective against psoriasis, although 20–30% of patients are nonresponders. Few pharmacogenomic studies have been performed to predict the response to anti-TNF drugs in psoriasis. We studied 173 polymorphisms to establish an association with the response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis (N=144). We evaluated the response using PASI75 at 3, 6 and 12 months. The results of the multivariate analysis showed an association between polymorphisms in PGLYR4, ZNF816A, CTNNA2, IL12B, MAP3K1 and HLA-C genes and the response at 3 months. Besides, the results for polymorphisms in IL12B and MAP3K1 were replicated at 6 months. We also obtained significant results for IL12B polymorphism at 1 year. Moreover, polymorphisms in FCGR2A, HTR2A and CDKAL1 were significant at 6 months. This is the first study to show an association with these polymorphisms. However, these biomarkers should be validated in large-scale studies before implementation in clinical practice
Files in this item
Google Scholar:Prieto-Pérez, R.
-
Solano-López, G.
-
Cabaleiro, T.
-
Román, M.
-
Ochoa, D.
-
Talegón, M.
-
Baniandrés, O.
-
López-Estebaranz, J. L.
-
de la Cueva, P.
-
Daudén Tello, Esteban
-
Abad Santos, Francisco
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.