Effects of photodynamic therapy on dermal fibroblasts from xeroderma pigmentosum and Gorlin-Goltz syndrome patients
Entity
UAM. Departamento de Biología; UAM. Departamento de MedicinaPublisher
Impact JournalsDate
2017-08-24Citation
10.18632/oncotarget.20485
Oncotarget 8.44 (2017): 77385-77399
ISSN
1949-2553DOI
10.18632/oncotarget.20485Funded by
FL and AJ were supported, respectively, by grants PI14/00931 and PI15/00974, from Instituto de Salud Carlos III, MINECO and Feder Funds and by S2010/BMD-2359 from Comunidad de Madrid. MDR was supported by grant S2010/BMD-2420 from Comunidad de Madrid and SAF2013-43475-R from MINECO. AZ was supported by S2010/BMD-2359 from Comunidad de MadridProject
Gobierno de España. PI14/00931; Gobierno de España. PI15/00974; Comunidad de Madrid. S2010/ BMD-2359/SKINMODEL; Comunidad de Madrid. S2010/BMD-2420/ CELLCAM; Gobierno de España. SAF2013-43475-REditor's Version
https://doi.org/10.18632/oncotarget.20485Subjects
Photodynamic therapy; Ultraviolet light; Cancer-associated fibroblasts; Gorlin-Goltz syndrome; Xeroderma pigmentosum; Biología y Biomedicina / BiologíaRights
© 2017 Zamarrón et al.Abstract
PDT is widely applied for the treatment of non-melanoma skin cancer premalignant
and malignant lesions (actinic keratosis, basal cell carcinoma and in
situ squamous cell carcinoma). In photodynamic therapy (PDT) the interaction
of a photosensitizer (PS), light and oxygen leads to the formation of reactive
oxygen species (ROS) and thus the selective tumor cells eradication. Xeroderma
pigmentosum (XP) and Gorlin-Goltz Syndrome (GS) patients are at high risk of
developing skin cancer in sun-exposed areas. Therefore, the use of PDT as a
preventive treatment may constitute a very promising therapeutic modality for
these syndromes. Given the demonstrated role of cancer associated fibroblasts
(CAFs) in tumor progression and the putative CAFs features of some cancerprone
genodermatoses fibroblasts, in this study, we have further characterized
the phenotype of XP and GS dermal fibroblasts and evaluated their response to
methyl-δ-aminolevulinic acid (MAL)-PDT compared to that of dermal fibroblasts
obtained from healthy donors. We show here that XP/GS fibroblasts display clear
features of CAFs and present a significantly higher response to PDT, even after
being stimulated with UV light, underscoring the value of this therapeutic approach
for these rare skin conditions and likely to other forms of skin cancer were CAFs
play a major role
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Google Scholar:Zamarrón, Alicia
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García, Marta
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Río, Marcela del
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Larcher, Fernando
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Juarranz de la Fuente, Ángeles
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