Survival in Southern European patients waitlisted for kidney transplant after graft failure: A competing risk analysis
Entity
UAM. Departamento de Economía AplicadaPublisher
Public Library of ScienceDate
2018-01-01Citation
10.1371/journal.pone.0193091
PLoS ONE 13.3 (2018): e0193091
ISSN
1932-6203DOI
10.1371/journal.pone.0193091Funded by
This study was supported in part by the Spanish Ministry of Economy and Competitiveness (MINECO) (grant ICI14/00016) from the Instituto de Salud Carlos III co-funded by the Fondo Europeo de Desarrollo Regional±FEDER, RETICS (REDINREN RD16/0009/0006, RD16/0009/0031)Project
Gobierno de España. ICI14/00016; Gobierno de España. RD16/0009/0006; Gobierno de España. RD16/0009/0031Editor's Version
https://doi.org/10.1371/journal.pone.0193091Subjects
Patients waitlisted; Transplant after failure; Kidney graft; Competing risk; Post-graft failure group; MedicinaRights
© 2018 Hernández et alAbstract
Background Whether patients waitlisted for a second transplant after failure of a previous kidney graft have higher mortality than transplant-näive waitlisted patients is uncertain. Methods We assessed the relationship between a failed transplant and mortality in 3851 adult KT candidates, listed between 1984–2012, using a competing risk analysis in the total population and in a propensity score-matched cohort. Mortality was also modeled by inverse probability weighting (IPTW) competing risk regression. Results At waitlist entry 225 (5.8%) patients had experienced transplant failure. All-cause mortality was higher in the post-graft failure group (16% vs. 11%; P = 0.033). Most deaths occurred within three years after listing. Cardiovascular disease was the leading cause of death (25.3%), followed by infections (19.3%). Multivariate competing risk regression showed that prior transplant failure was associated with a 1.5-fold increased risk of mortality (95% confidence interval [CI], 1.01–2.2). After propensity score matching (1:5), the competing risk regression model revealed a subhazard ratio (SHR) of 1.6 (95% CI, 1.01–2.5). A similar mortality risk was observed after the IPTW analysis (SHR, 1.7; 95% CI, 1.1–2.6). Conclusions Previous transplant failure is associated with increased mortality among KT candidates after relisting. This information is important in daily clinical practice when assessing relisted patients for a retransplant.
Files in this item
Google Scholar:Hernández, Domingo
-
Muriel, Alfonso
-
Castro de La Nuez, Pablo
-
Alonso-Titos, Juana
-
Ruiz-Esteban, Pedro
-
Duarte, Ana
-
Gonzalez-Molina, Miguel
-
Palma, Eulalia
-
Alonso, Manuel
-
Torres, Armando
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study)
Pérez-Sáez, María José; Lafuente Covarrubias, Omar; Hernández, Domingo; Moreso, Francesc; Melilli, Edoardo; Juega, Javier; Sousa, Erika de; López-Sánchez, Paula; Rodríguez-Ferrero, María Luisa; Maruri-Kareaga, Naroa; Navarro, María Dolores; Valero, Rosalía; Mazuecos, María Auxiliadora; LLamas, Francisco; Martín-Moreno, Paloma; Fernández-García, Antón; Espí, Jordi; Jiménez, Carlos; Ramos, Ana; Gavela, Eva; Portolés Pérez, José María; Behalf of the GEODAS Group
2019-06-26 -
Correction: Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) (Bone Marrow Transplantation, (2020), 55, 4, (681-694), 10.1038/s41409-019-0718-7)
Snowden, John A.; Saccardi, Riccardo; Orchard, Kim; Ljungman, Per; Duarte Palomino, Rafael; Labopin, Myriam; McGrath, Eoin; Brook, Nigel; de Elvira, Carmen Ruiz; Gordon, Debra; Poirel, Hélène A.; Ayuk, Francis; Beguin, Yves; Bonifazi, Francesca; Gratwohl, Alois; Milpied, Noel; Moore, John; Passweg, Jakob; Rizzo, J. Douglas; Spellman, Stephen R.; Sierra, Jorge; Solano, Carlos; Sanchez-Guijo, Fermin; Worel, Nina; Gusi, Andreu; Adams, Gillian; Balan, Theodor; Baldomero, Helen; Macq, Gilles; Marry, Evelyne; Mesnil, Florence; Oldani, Elena; Pearce, Rachel; Perry, Julia; Raus, Nicole; Schanz, Urs; Tran, Steven; Wilcox, Leonie; Basak, Grzegorz W.; Chabannon, Christian; Corbacioglu, Selim; Dolstra, Harry; Kuball, Jürgen; Mohty, Mohamad; Lankester, Arjan; Montoto, Sylvia; Nagler, Arnon; Styczynski, Jan; Yakoub-Agha, Ibrahim; de Latour, Regis Peffault; Kroeger, Nicolaus; Brand, Ronald; de Wreede, Liesbeth C.; van Zwet, Erik; Putter, Hein
2020-04-01