Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location
Author
Brandariz, Lorena; Arriba, María; García, Juan Luis; Cano, Juana María; Rueda, Daniel; Rubio, Eduardo; Rodríguez, Yolanda; Pérez, Jessica; Vivas, Alfredo; Sánchez, Carmen; Tapial, Sandra; Pena, Laura; García Arranz, Mariano Andrés; García Olmo, Damián; Urioste, Miguel; González-Sarmiento, Rogelio; Perea, JoséEntity
UAM. Departamento de Cirugía; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ); Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
Impact JournalsDate
2018-01-01Citation
10.18632/oncotarget.24502
Oncotarget 9.20 (2018): 15302-15311
ISSN
1949-2553DOI
10.18632/oncotarget.24502Funded by
This work was funded by Projects PI10/0683, PI13/01741, PI13/0127 and PI14/00459 from the Spanish Ministry of Health and Consumer Affairs and FEDER, and was approved by the Ethics Committee of our InstitutionProject
Gobierno de España. PI10/0683; Gobierno de España. PI13/0127; Gobierno de España. PI13/0127; Gobierno de España. PI14/00459Editor's Version
https://doi.org/10.18632/oncotarget.24502Subjects
Chromosomal instability; Colon location; CpG island methylator phenotype; Late-onset colorectal cancer; Microsatellite instability; MedicinaRights
© Brandariz et alAbstract
Background: Since there is a predilection of some clinical and molecular features
for a given tumor location, we assessed whether this can be confirmed in late-onset
colorectal cancer (LOCRC).
Results: Right colon cancers showed features associated with sporadic
Microsatellite Instability: predominance of female cases and BRAF mutations, and
an important mucinous component. Left colon cancers developed a higher number
of polyps and multiple primary CRCs, showed the strongest familial component, and
had better prognosis. Rectal cancers showed a predominantly sporadic phenotype,
with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy
number alterations (CNAs) greater than or equal to 50% were observed in this
LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11,
and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA
were the only mutated genes showing differences according to the tumor location,
mainly for right colon cancers.
Materials and Methods: We analyzed clinical and molecular characteristics of
LOCRC at different tumor locations in order to determine if there are differential
phenotypes related with the location in the colon.
Conclusions: Categorizing LOCRC according to tumor location appears to be an
adequate first step to resolving the heterogeneity of this subset of CRC
Files in this item
Google Scholar:Brandariz, Lorena
-
Arriba, María
-
García, Juan Luis
-
Cano, Juana María
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Rueda, Daniel
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Rubio, Eduardo
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Rodríguez, Yolanda
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Pérez, Jessica
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Vivas, Alfredo
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Sánchez, Carmen
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Tapial, Sandra
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Pena, Laura
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García Arranz, Mariano Andrés
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García Olmo, Damián
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Urioste, Miguel
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González-Sarmiento, Rogelio
-
Perea, José
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