Unravelling drug-induced hypertension: Molecular mechanisms of aldosterone-independent mineralocorticoid receptor activation by posaconazole
Entity
UAM. Departamento de Medicina; Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)Publisher
Oxford University Press on behalf of ERA-EDTADate
2018-10-01Citation
10.1093/ckj/sfy087
Clinical Kidney Journal 11.5 (2018): 688–690
ISSN
2048-8505 (print); 2048-8513 (online)DOI
10.1093/ckj/sfy087Funded by
The authors were supported by FIS PI16/02057, PI18/01366, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet MS14/00133 to M.D.S.-N.Project
Gobierno de España. FIS PI16/02057; Gobierno de España. PI18/01366; Gobierno de España. RD016/0009; Comunidad de Madrid. B2017/BMD-3686/CIFRA2Editor's Version
https://doi.org/10.1093/ckj/sfy087Subjects
11-deoxycortisol; 11b-hydroxylase; 11b-hydroxysteroid dehydrogenase 2; Antifungal; Drug-induced hypertension; MedicinaRights
© The Author(s) 2018Abstract
Drug-induced hypertension offers the opportunity to further understand pathways involved in the regulation of blood pressure. Posaconazole is an antifungal agent known to induce hypertension and hypokalaemia. In recent months, a flurry of reports has unravelled the metabolic processes involved. In this issue of CKJ, Barton K, Davis TK, Marshall B et al. Posaconazole-induced hypertension and hypokalemia due to inhibition of the 11β-hydroxylase enzyme. Clin Kidney J 2018; 11: 691-693 present convincing evidence of 11β-hydroxylase inhibition resulting in a biochemical syndrome resembling genetic congenital adrenal hyperplasia and characterized by high 11-deoxycorticosterone and 11-deoxycortisol levels as well as androgen levels. This adds to prior evidence supporting inhibition of 11β-hydroxysteroid dehydrogenase 2, the enzyme that inactivates cortisol in aldosterone-sensitive tissues such as the kidneys, yielding a syndrome resembling genetic apparent mineralocorticoid excess or licorice toxicity, characterized by a high cortisol/cortisone ratio
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Google Scholar:Sánchez Niño, María Dolores
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Ortiz Arduán, Alberto
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