Physicochemical and biological interactions between cerium oxide nanoparticles and a 1,8-naphthalimide derivative
Entity
UAM. Departamento de Biología; UAM. Departamento de Química Física AplicadaPublisher
ElsevierDate
2017-05-10Citation
10.1016/j.jphotobiol.2017.05.009
Journal of Photochemistry and Photobiology B: Biology 172.1 (2017): 2069-2075
ISSN
1011-1344 (print); 1873-2682 (online)DOI
10.1016/j.jphotobiol.2017.05.009Funded by
This research was supported by CTM2013-45775-C2-1-R and CTM2013-45775-C2-2-R grants from MINECO. Cerium oxide nanoparticles were kindly provided by S. Seal and S. Das (University of Central Florida, U.S.A). Gerardo Pulido-Reyes thanks the Spanish Ministry of Education for the award of an FPU grant (FPU12/01796)Project
Gobierno de España. CTM2013-45775-C2-1-R; Gobierno de España. CTM2013-45775-C2-2-REditor's Version
https://doi.org/10.1016/j.jphotobiol.2017.05.009Subjects
1,8-naphthalimide; Adsorption; Bioactivity; Cerium oxide nanoparticles; Mixture toxicity; Biología y Biomedicina / Biología; QuímicaNote
This Accepted Manuscript is available for reuse under a CC BY-NC-ND licence after the 24 month embargo period provided that all the terms of the licence are adhered toRights
© 2017 Elsevier B.V.Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Abstract
Cerium (Ce) oxide nanoparticles (CNPs) have attracted attention due to their high bioactivity and unique redox-chemistry. The oxygen vacancies at the surface of the nanoparticle explain the autocatalytic properties of CNPs in which the Ce3+ atoms occupy the center of the oxygen vacancies surrounded by Ce4+ atoms. Until now, CNPs have been associated with organic molecules at the synthesis stage to extend their applications or improve their stability. However, there is a lack of information regarding the post-synthesis interaction of CNPs and organic molecules that could enhance or induce new properties. Due to their unique optical properties and their many uses in different areas such as supramolecular chemistry or biomedicine, we have chosen a derivative from the family of naphthalimides (the 4-amino-1,8-naphthalimide-N-substituted; ANN) to study the interaction with different CNPs (CNP1-4) and their joint bioactivity compared to that of the same compounds alone. ANN-CNP complexes were formed as revealed by spectroscopic studies, but, the interaction was markedly different depending on the physicochemical properties of CNPs and their surface content of Ce3+ sites. The ANN adsorption on all CNPs involved the amino group in the naphthalene moiety as shown by NMR spectroscopy, while the pyrrolidine ring was mainly involved in the specific interaction between ANN and CNP1. The biological effect of each CNP and ANN individually and forming complexes was assessed using a bioluminescent model bacterium. The results showed that ANN and CNP with the higher content of surface Ce3+ (CNP1) when combined acted additively towards the used model organism. In the opposite, ANN-CNP2, ANN-CNP3 and ANN-CNP4 complexes were antagonistic when the nanoparticles dominated the mixture. The results of this study contribute to expand the knowledge of the interaction between nanoparticles and organic molecules which may be useful for understanding the behavior of nanoparticles in complex matrices
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Google Scholar:Pulido-Reyes, Gerardo
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Martín García, Esperanza
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Gu. Coronado, J. L.
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Leganés Nieto, Francisco
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Rosal, Roberto
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Fernández Piñas, Francisca
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