Thermodynamic and Kinetic Stabilities of G-Quadruplexes in Apolar Solvents
Entity
UAM. Departamento de Química Orgánica; UAM. Instituto de Investigación Avanzada en Ciencias Químicas (IAdChem)Publisher
American Chemical SocietyDate
2017-01-19Citation
10.1021/acs.orglett.6b03606
Organic Letters 19.3 (2017): 460-463
ISSN
1523-7060 (print); 1523-7052 (online)DOI
10.1021/acs.orglett.6b03606Funded by
The EU (ERC-Starting Grant 279548) and MINECO (CTQ2014-57729-P) is gratefully acknowledged. E.F. thanks Sharif University of Technology of Iran for financial support. M.M.-A. acknowledges a FPI grant from MINECOProject
info:eu-repo/grantAgreement/EC/FP7/279548; Gobierno de España. CTQ2014-57729-PEditor's Version
http://dx.doi.org/10.1021/acs.orglett.6b03606Subjects
G-Quadruplexes; Self assembly; Circular dichroism; QuímicaNote
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03606Rights
© 2017 American Chemical SocietyAbstract
In contrast to more polar media, G-quadruplex assembly reveals remarkably high thermodynamic and kinetic stability in toluene solutions. Depending on the substituents installed at the lipophilic guanosine, either a dodecamer or an octamer complex is formed in the presence of K+ or Na+ salts that resist conditions of high dilution and elevated temperatures without exhibiting significant dissociation. Moreover, kinetic exchange between complexed and uncomplexed G is slow enough in NMR to monitor G-quadruplex formation along a day time scale
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Google Scholar:Fadaei, Elham
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Martín-Arroyo, Miguel
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Tafazzoli, Mohsen
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González Rodríguez, David
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