Thermodynamic and Kinetic Stabilities of G-Quadruplexes in Apolar Solvents
Entidad
UAM. Departamento de Química Orgánica; UAM. Instituto de Investigación Avanzada en Ciencias Químicas (IAdChem)Editor
American Chemical SocietyFecha de edición
2017-01-19Cita
10.1021/acs.orglett.6b03606
Organic Letters 19.3 (2017): 460-463
ISSN
1523-7060 (print); 1523-7052 (online)DOI
10.1021/acs.orglett.6b03606Financiado por
The EU (ERC-Starting Grant 279548) and MINECO (CTQ2014-57729-P) is gratefully acknowledged. E.F. thanks Sharif University of Technology of Iran for financial support. M.M.-A. acknowledges a FPI grant from MINECOProyecto
info:eu-repo/grantAgreement/EC/FP7/279548; Gobierno de España. CTQ2014-57729-PVersión del editor
http://dx.doi.org/10.1021/acs.orglett.6b03606Materias
G-Quadruplexes; Self assembly; Circular dichroism; QuímicaNota
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03606Derechos
© 2017 American Chemical SocietyResumen
In contrast to more polar media, G-quadruplex assembly reveals remarkably high thermodynamic and kinetic stability in toluene solutions. Depending on the substituents installed at the lipophilic guanosine, either a dodecamer or an octamer complex is formed in the presence of K+ or Na+ salts that resist conditions of high dilution and elevated temperatures without exhibiting significant dissociation. Moreover, kinetic exchange between complexed and uncomplexed G is slow enough in NMR to monitor G-quadruplex formation along a day time scale
Lista de ficheros
Google Scholar:Fadaei, Elham
-
Martín-Arroyo, Miguel
-
Tafazzoli, Mohsen
-
González Rodríguez, David
Lista de colecciones del ítem
Registros relacionados
Mostrando ítems relacionados por título, autor, creador y materia.