New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
Editor
Frontiers MediaFecha de edición
2018-12-06Cita
10.3389/fimmu.2018.02894
Frontiers in Immunology 9 (2018): 2894
ISSN
1664-3224DOI
10.3389/fimmu.2018.02894Financiado por
The research developed in our laboratories is supported by grants SAF2017-84183-R from the Spanish Ministry of Science, Innovation and Universities to MQ, and APQ-04269-10 and RED-00011-14 from the Foundation for Research Support of the State of Minas Gerais (FAPEMIG) to EFProyecto
Gobierno de España. SAF2017-84183-RVersión del editor
https://doi.org/10.3389/fimmu.2018.02894Materias
Cancer; HLA-G; Immunosurveillance; MHC-I; Qa-2; MedicinaResumen
It is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the presentation of tumor antigens to the immune system in order to activate a response against tumor cells. However, a larger family of non-classical MHC class Ib-related molecules has received less attention. In this mini-review, we discuss the role of class Ib murine Qa-2 and its proposed human HLA-G homolog on immunosurveillance during embryogenesis and cancer. Whereas, both HLA-G and Qa-2 are involved in immune tolerance in pregnancy, the current evidence suggests that they play opposite roles in cancer. HLA-G appears to promote tumor progression while Qa-2 acts as a tumor suppressor awaking the immune system to reject tumor cells, as suggested by studies on different cancer cell models, such as melanoma, lymphoma, lung carcinoma, and our own results in mammary carcinoma.
Lista de ficheros
Google Scholar:Da Silva, Istéfani L.
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Montero-Montero, Lucía
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Ferreira, Enio
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Quintanilla, Miguel
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