CD30-positive primary cutaneous lymphoproliferative disorders: Molecular alterations and targeted therapies
Entidad
UAM. Departamento de Anatomía Patológica; UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Editor
Ferrata Storti FoundationFecha de edición
2019-01-31Cita
10.3324/haematol.2018.197152
Haematologica 104.2 (2019): 226-235
ISSN
0390-6078 (print); 1592-8721 (online)DOI
10.3324/haematol.2018.197152Financiado por
This work was supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO, RTICC ISCIII and CIBERONC) (SAF2013-47416-R, RD06/0020/0107-RD012/0036/0060 and Plan Nacional I+D+I: PI17/2172, PI16/01294 and PIE15/0081), AECC and the Madrid Autonomous Community.Proyecto
Gobierno de España. SAF2013-47416-R; Gobierno de España. RD06/0020/0107; Gobierno de España. RD012/0036/0060; Gobierno de España. PI17/2172; Gobierno de España. PI16/01294; Gobierno de España. PIE15/0081Versión del editor
https://doi.org/10.3324/haematol.2018.197152Materias
CD30-positive; T-cell; Lymphoproliferative; Cutaneous; Molecular alterations; MedicinaDerechos
© 2019 Ferrata Storti FoundationResumen
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Molecular studies of primary cutaneous anaplastic large cell lymphoma reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and their potential as therapeutic targets.
Lista de ficheros
Google Scholar:Prieto-Torres, Lucia
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Rodriguez-Pinilla, Socorro M.
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Onaindia, Arantza
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Ara, Mariano
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Requena Caballero, Luis
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Piris, Miguel
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