Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study
Entidad
UAM. Departamento de MedicinaEditor
Medicina OralFecha de edición
2019-09-01Cita
10.4317/medoral.23011
Med Oral Patol Oral Cir Bucal 24.5 (2019): e603-9
ISSN
1698-4447 (print); 1698-6946 (online)DOI
10.4317/medoral.23011Versión del editor
http://dx.doi.org/doi:10.4317/medoral.23011Materias
oral cancer; oral squamous cell carcinoma; histologic risk assessment; oral cancer recurrence; MedicinaDerechos
© Medicina Oral S.L.Resumen
Background: More than 90% of malignant tumors diagnosed in the oral cavity are Oral Squamous Cell Carcinomas (OSCC) whose preferred location is the tongue. Classically, this disease has affected men preferentially,
although recent studies suggest that trends are changing and the proportion of women with OSCC is increasing.
In addition, the prevalence of oral cancer is also determined by some risk factors as alcohol consumption and tobacco. Currently, the Tumor, Node, Metastasis (TNM) classification is employed to defined tumor stage and based
on this guide specific treatments are established. However, 5-year-survival does not exceed 50% of cases. The
objective of this study is to determine whether a histological risk pattern indicative of higher recurrence might be
present in T1-T2 tumors located in the anterior two thirds of the tongue.
Material and Methods: Samples from 26 patients with OSCC were analyzed and histological risk pattern of recurrent and non-recurrent tumors were compared. We have analyzed histological variables described in Anneroth
and Brandwein-Gensler classifications. Additionally, we have also examined both clinical variables such as age,
sex or comorbidities, as well as habits such as tobacco or alcohol consumption.
Results: We found that sex (male) and keratinization degree (high or moderate) are directly related with OSCC
recurrence. In fact, free illness time is lower in men and higher in those cases with minimal or no keratinization.
Conclusions: Based on the variables analyzed, it has not been possible to establish a histological risk pattern that,
complementary to the TNM classification, could have a predictive role in these early-stage tongue carcinomas
Lista de ficheros
Google Scholar:Migueláñez Medrán, Carmen
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Pozo Kreilinger, José Juan
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Cebrián Carretero, José Luis
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Martínez García, Miguel Angel
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López Sánchez, Antonio Francisco
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