Clinical infections by herpesviruses in patients treated with valproic acid: A nested case-control study in the Spanish Primary Care Database, BIFAP
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología; UAM. Departamento de Biología MolecularPublisher
MDPI, Basel, SwitzerlandDate
2019-09-11Citation
10.3390/jcm8091442
Journal of Clinical Medicine 8.9 (2019): 1442
ISSN
2077-0383DOI
10.3390/jcm8091442Editor's Version
https://doi.org/10.3390/jcm8091442Subjects
BIFAP; Valproic acid; Herpesvirus infections; Case-control study; Electronic health care database; MedicinaRights
© 2019 by the authors.Abstract
The objective of this study is to evaluate the risk of clinical infections by herpesviruses in
patients exposed to valproic acid (VPA).We performed a case-control study nested in a primary cohort
selected from the Spanish primary care population-based research database BIFAP (Base de datos para
la Investigación Farmacoepidemiológica en Atención Primaria) over the period 2001–2015. The events
of interest were those diseases caused by any herpesviruses known to infect humans. For each
case, up to 10 controls per case matched by age, gender, and calendar date were randomly selected.
A conditional logistic regression was used to compute adjusted odds ratios (OR) and their 95%
confidence intervals (95% CI). Current use of VPA was associated with a trend towards a reduced risk
of clinical infections by herpesviruses as compared with non-users (OR 0.84; CI 95% 0.7–1.0; p = 0.057).
Among current users, a trend to a decreased risk with treatment durations longer than 90 days was
also observed. The results show a trend to a reduced risk of clinical infection by herpesviruses in
patients exposed to VPA. These results are consistent with those in vitro studies showing that, in
cultured cells, VPA can inhibit the production of the infectious progeny of herpesviruses. This study
also shows the efficient use of electronic healthcare records for clinical exploratory research studies
Files in this item
Google Scholar:Gil, Miguel
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González-González, Rocío
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Vázquez-Calvo, Ángela
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Álvarez-Gutiérrez, Arturo
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Martín-Acebes, Miguel A.
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Praena, Beatriz
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Bello-Morales Arroyo, Ángeles Raquel
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Saiz, Juan-Carlos
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López Guerrero, José Antonio
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Tabarés, Enrique
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Sobrino, Francisco
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