Signal integration and transcriptional regulation of the inflammatory response mediated by the GM-/MCSF signaling axis in human monocytes
Autor (es)
Rodríguez, Ramón M.; Suárez-Álvarez, Beatriz; Lavín, José L.; Ascensión, Alex M.; González, Monika; Lozano, Juan J.; Raneros, Aroa B.; Bulnes, Paula D.; Vidal-Castiñeira, Jose R.; Huidobro, Covadonga; Martín-Martín, Cristina; Sanz, Ana B.; Ruiz Ortega, Marta; Puig-Kröger, Amaya; Corbi, Ángel L.; Araúzo-Bravo, Marcos J.; Aransay, Ana M.; López-Larrea, CarlosEntidad
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Editor
Elsevier Inc.Fecha de edición
2019Cita
10.1016/j.celrep.2019.09.035
Cell Reports .29.4 (2019): 860-872.e5
ISSN
2211-1247 (print); 2211-1247 (online)DOI
10.1016/j.celrep.2019.09.035Financiado por
This work was supported by grants from the Plan Nacional de I+D+I 2013– 2016 ISCIII (Institute of Health Carlos III; PI16/01318, PI17/01244, PI17/ 0119, PI16/1900, and PI19/00184); the Gobierno del Principado de Asturias; the PCTI-Plan de Ciencia, Tecnologı´a e Innovacio´ n 2013-2017 (grant IDI/ 2018/144); FEDER ‘‘Funding Program of the European Union’’; the Red Española de Investigación Renal (REDinREN) (RD16/0009/0020, RD016/0009/002, and RD016/0009/001); the Agencia Estatal de Investigación (AEI) (ayuda Juan de la Cierva-Incorporaciόn; IJCI-2017-33347 to R.M.R.); and the Instituto de Salud Carlos III (Contratos Sara Borrell; CD16/00033 to C.H.). CIC bioGUNE support was provided by the Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs), the Innovation Technology Department of Bizkaia County, the CIBERehd Network, and Spanish MINECO, the Severo Ochoa Excellence Accreditation (SEV-2016-0644)Proyecto
Gobierno de España. PI16/01318; Gobierno de España. PI17/01244; Gobierno de España. PI17/ 0119; Gobierno de España. PI16/1900; Gobierno de España. PI19/00184; Gobierno de España. RD16/0009/0020; Gobierno de España. RD016/0009/002; Gobierno de España. RD016/0009/001Versión del editor
https://doi.org/10.1016/j.celrep.2019.09.035Materias
Epigenetics; Gm-Csf; M-Csf; DNA Methylation; Chromatin; Monocyte; Macrophage; Polarization; Differentiation; Plasticity; MedicinaDerechos
© 2019 The AuthorsEsta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Resumen
In recent years, the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines have been identified as opposing regulators of the inflammatory program. However, the two cytokines are simultaneously present in the inflammatory milieu, and it is not clear how cells integrate these signals. In order to understand the regulatory networks associated with the GM/M-CSF signaling axis, we analyzed DNA methylation in human monocytes. Our results indicate that GM-CSF induces activation of the inflammatory program and extensive DNA methylation changes, while M-CSF-polarized cells are in a less differentiated state. This inflammatory program is mediated via JAK2 associated with the GM-CSF receptor and the downstream extracellular signal-regulated (ERK) signaling. However, PI3K signaling is associated with a negative regulatory loop of the inflammatory program and M-CSF autocrine signaling in GM-CSF-polarized monocytes. Our findings describe the regulatory networks associated with the GM/M-CSF signaling axis and how they contribute to the establishment of the inflammatory program associated with monocyte activation.
Lista de ficheros
Google Scholar:Rodríguez, Ramón M.
-
Suárez-Álvarez, Beatriz
-
Lavín, José L.
-
Ascensión, Alex M.
-
González, Monika
-
Lozano, Juan J.
-
Raneros, Aroa B.
-
Bulnes, Paula D.
-
Vidal-Castiñeira, Jose R.
-
Huidobro, Covadonga
-
Martín-Martín, Cristina
-
Sanz, Ana B.
-
Ruiz Ortega, Marta
-
Puig-Kröger, Amaya
-
Corbi, Ángel L.
-
Araúzo-Bravo, Marcos J.
-
Aransay, Ana M.
-
López-Larrea, Carlos
Lista de colecciones del ítem
Registros relacionados
Mostrando ítems relacionados por título, autor, creador y materia.
-
The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB
Moreno, Juan A.; Izquierdo, María Concepción; Sánchez Niño, María Dolores; Suárez-Álvarez, Beatriz; López-Larrea, Carlos; Jakubowski, Aniela; Blanco-Parra, Jualia A.; Ramírez Tapia, Rafael; Selgas Gutiérrez, Rafael; Ruiz Ortega, Marta; Egido de los Ríos, Jesús; Ortiz Arduán, Alberto; Sanz, Ana Belén
2011-07-01 -
Epigenetic modulation of gremlin-1/NOTCH pathway in experimental crescentic immune-mediated glomerulonephritis
Tejedor Santamaria, Lucia; Morgado-Pascual, Jose Luis; Marquez-Exposito, Laura; Suarez-Alvarez, Beatriz; Rodrigues-Diez, Raul R.; Tejera-Muñoz, Antonio; Marchant, Vanessa; Mezzano, Sergio; Lopez-Larrea, Carlos; Sola, Anna; Fernandez-Juarez, Gema Maria; Ortiz Arduán, Alberto; Rayego-Mateos, Sandra; Ruiz Ortega, Marta
2022-01-20