Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination
Entity
UAM. Departamento de Psicología Biológica y de la SaludPublisher
Nature ResearchDate
2020-12-01Citation
10.1038/s41598-020-61169-x
Scientific Reports 10.1(2020): 4075
ISSN
2045-2322DOI
10.1038/s41598-020-61169-xEditor's Version
https://doi.org/10.1038/s41598-020-61169-xSubjects
Ayahuasca; Hallucinogen; Traditional medicin; Amazonian regions; Depression and psychopathology; PsicologíaRights
© 2019 The AuthorsAbstract
Ayahuasca is a hallucinogenic decoction used as a traditional medicine in several Amazonian regions. The ritualistic use of ayahuasca has spread throughout many countries, making it necessary to study its risks and benefits. Two sub-studies were designed for this investigation. In sub-study 1, a psychiatric interview and a battery of questionnaires were administered to subjects (n = 40) before their first ayahuasca use. Two follow-ups were conducted at 1 and 6 months. In sub-study 2, the same interview and battery of questionnaires were administered to long-term ayahuasca users (n = 23) and their scores were compared with those of the ayahuasca-naïve group. In the first assessment, nearly half (45%) of the naïve users were found to meet the diagnostic criteria for a psychiatric disorder. After the ayahuasca use, more than 80% of those subjects showed clinical improvements that persisted at 6 months. The questionnaires showed significant reductions in depression and psychopathology. Regarding sub-study 2, long-term users showed lower depression scores, and higher scores for self-transcendence and quality of life, as compared to their peers in sub-study 1. Further controlled and observational naturalistic studies assessing the eventual risks and potential benefits of ayahuasca are warranted.
Files in this item
Google Scholar:Jiménez-Garrido, Daniel F.
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Gómez-Sousa, María
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Ona, Genís
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Dos Santos, Rafael G.
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Hallak, Jaime E.C.
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Alcázar-Córcoles, Miguel Ángel
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Bouso, José Carlos
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