The relationship between physical activity, apolipoprotein e ϵ4 carriage, and brain health
Author
De Frutos-Lucas, Jaisalmer; Cuesta, Pablo; López-Sanz, David; Peral-Suárez, África; Cuadrado-Soto, Esther; Ramírez-Toranõ, Federico; Brown, Belinda M.; Serrano Rodríguez, Juan Manuel; Laws, Simon M.; Rodríguez-Rojo, Inmaculada C.; Verdejo-Román, Juan; Brun, Ricardo; Delgado-Losada, Maria L.; Barabash, Ana; López-Sobaler, Ana M.; López-Higes, Ramón; Marcos, Alberto; Maestú, FernandoEntity
UAM. Departamento de Psicología Biológica y de la SaludPublisher
BMCDate
2020-04-24Citation
10.1186/s13195-020-00608-3
Alzheimer's Research & Therapy 12.1 (2020): 48
ISSN
1758-9193 (online)DOI
10.1186/s13195-020-00608-3Funded by
This study was funded by the Spanish Ministry of Economy and Competitiveness under the Grant PSI2015-68793-C3-1-R [D601] and by the project B2017/BMD-3760 from NEUROCENTRO. Complimentary, it was supported by a predoctoral fellowship from La Caixa Foundation to JFL, a postdoctoral fellowship from the Spanish Ministry of Economy and Competitiveness to PC (FJCI-2015-26755), a grant from the Spanish Ministry of Science, Innovation and Universities to JVR (FJCI-2017-33396), and a predoctoral grant by the Spanish Ministry of Economy (BES-2016-076869) to FRT.Project
Gobierno de España. PSI2015-68793-C3-1-R [D601; Comunidad de Madrid. B2017/BMD-3760/NEURO-CENTROEditor's Version
https://doi.org/10.1186/s13195-020-00608-3Subjects
Alzheimer's disease; APOE; MEG; Physical activity; Synaptic function; Temporal lobe; PsicologíaRights
© 2020 Author(s)Abstract
Background: Neuronal hyperexcitability and hypersynchrony have been described as key features of neurophysiological dysfunctions in the Alzheimer's disease (AD) continuum. Conversely, physical activity (PA) has been associated with improved brain health and reduced AD risk. However, there is controversy regarding whether AD genetic risk (in terms of APOE ϵ4 carriage) modulates these relationships. The utilization of multiple outcome measures within one sample may strengthen our understanding of this complex phenomenon. Method: The relationship between PA and functional connectivity (FC) was examined in a sample of 107 healthy older adults using magnetoencephalography. Additionally, we explored whether ϵ4 carriage modulates this association. The correlation between FC and brain structural integrity, cognition, and mood was also investigated. Results: A relationship between higher PA and decreased FC (hyposynchrony) in the left temporal lobe was observed among all individuals (across the whole sample, in ϵ4 carriers, and in ϵ4 non-carriers), but its effects manifest differently according to genetic risk. In ϵ4 carriers, we report an association between this region-specific FC profile and preserved brain structure (greater gray matter volumes and higher integrity of white matter tracts). In this group, decreased FC also correlated with reduced anxiety levels. In ϵ4 non-carriers, this profile is associated with improved cognition (working and episodic memory). Conclusions: PA could mitigate the increase in FC (hypersynchronization) that characterizes preclinical AD, being beneficial for all individuals, especially ϵ4 carriers.
Files in this item
Google Scholar:De Frutos-Lucas, Jaisalmer
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Cuesta, Pablo
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López-Sanz, David
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Peral-Suárez, África
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Cuadrado-Soto, Esther
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Ramírez-Toranõ, Federico
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Brown, Belinda M.
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Serrano Rodríguez, Juan Manuel
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Laws, Simon M.
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Rodríguez-Rojo, Inmaculada C.
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Verdejo-Román, Juan
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Brun, Ricardo
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Delgado-Losada, Maria L.
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Barabash, Ana
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López-Sobaler, Ana M.
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López-Higes, Ramón
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Marcos, Alberto
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Maestú, Fernando
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