Maternal psychological and biological factors associated to gestational complications
Entidad
UAM. Departamento de Farmacología; UAM. Departamento de Fisiología; UAM. Departamento de Obstetricia y Ginecología; UAM. Departamento de Psicología Biológica y de la Salud; UAM. Departamento de Química AgrícolaEditor
MDPIFecha de edición
2021-03-05Cita
10.3390/jpm11030183
Journal of Personalized Medicine 11 (2021): 183
ISSN
2075-4426DOI
10.3390/jpm11030183Versión del editor
https://doi.org/10.3390/jpm11030183Materias
anxiety; life satisfaction; life–work concerns; melatonin; cortisol; biopsychosocial model; obstetric complications; MedicinaDerechos
© 2021 by the authorsResumen
Early detection of gestational complications is a priority in obstetrics. In our social context,
this is linked to maternity age. Most studies are focused on biological factors. However, pregnancy
is also influenced by social and psychological factors, which have not been deeply explored. We
aimed to identify biopsychosocial risk and protective factors associated with the development of
maternal and fetal complications. We enrolled 182 healthy pregnant women, and plasma melatonin
and cortisol levels were measured in the first trimester by chemiluminescent immunoassays. At
different time points along gestation, women answered several questionnaires (positive and negative
affect schedule, hospital anxiety and depression scale, pregnancy concerns scale, life orientation
test, resilience scale, life satisfaction scale and life–work conflicts scale). They were followed up
until delivery and categorized as normal pregnancy, maternal or fetal complications. Maternal
complications were associated with low melatonin (OR = 0.99 [0.98; 1.00]; p-value = 0.08) and life
satisfaction (OR = 0.64 [0.41; 0.93]; p-value = 0.03) and fetal complications were associated with high
cortisol (OR = 1.06 [1.02; 1.13]; p-value = 0.04), anxiety (OR = 2.21 [1.10; 4.55]; p-value = 0.03) and
life–work conflicts (OR = 1.92 [1.04; 3.75]; p-value = 0.05). We conclude that psychological factors
influence pregnancy outcomes in association with melatonin and cortisol alterations. High maternal
melatonin and life satisfaction levels could be potential protective factors against the development of
maternal complications during pregnancy. Low anxiety and cortisol levels and reduced work–life
conflicts could prevent fetal complications
Lista de ficheros
Google Scholar:Ramiro-Cortijo, David
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De la Calle, Maria
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Benítez García, Vanesa
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Gila-Diaz, Andrea
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Moreno-Jimenez, Bernardo
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Arribas Rodríguez, Silvia Magdalena
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Garrosa Hernández, Eva
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