Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors
Author
Styczyński, Jan; Tridello, Gloria; Koster, Linda; Iacobelli, Simona; van Biezen, Anja; van der Werf, Steffie; Mikulska, Małgorzata; Gil, Lidia; Cordonnier, Catherine; Ljungman, Per; Averbuch, Diana; Cesaro, Simone; Cámara, Rafael de la; Baldomero, Helen; Bader, Peter; Basak, Grzegorz; Bonini, Chiara; Duarte Palomino, Rafael; Dufour, Carlo; Kuball, Jurgen; Lankester, Arjan; Montoto, Silvia; Nagler, Arnon; Snowden, John A.; Kröger, Nicolaus; Mohty, Mohamad; Gratwohl, AloisEntity
UAM. Departamento de MedicinaPublisher
Springer NatureDate
2019-08-27Citation
10.1038/s41409-019-0624-z
Bone Marrow Transplantation 55.1 (2020): 126-136
ISSN
0268-3369DOI
10.1038/s41409-019-0624-zFunded by
The study was funded by the European Group for Blood and Marrow Transplantation EBMTEditor's Version
https://doi.org/10.1038/s41409-019-0624-zSubjects
Haematopoietic stem cell transplantation (HSCT); Death; Leukemia; Infections; MedicinaRights
© 2019 The AuthorsAbstract
Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55′668 deaths in 114′491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of death at day 30 (very early), day 100 (early), at 1 year (intermediate) and at 5 years (late). Mortality from all causes decreased from cohort 1 (1980–2001) to cohort 2 (2002–2015) in all post-transplant phases after autologous HSCT. After allogeneic HSCT, mortality from infections, GVHD, and toxicity decreased up to 1 year, increased at 5 years; deaths from relapse increased in all post-transplant phases. Infections of unknown origin were the main cause of infectious deaths. Lethal bacterial and fungal infections decreased from cohort 1 to cohort 2, not unknown or mixed infections. Infectious deaths were associated with patient-, disease-, donor type, stem cell source, center, and country- related factors. Their impact varied over the post-transplant phases. Transplant centres have successfully managed to reduce death after HSCT in the early and intermediate post-transplant phases, and have identified risk factors. Late post-transplant care could be improved by focus on groups at risk and better identification of infections of “unknown origin”.
Files in this item
Google Scholar:Styczyński, Jan
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Tridello, Gloria
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Koster, Linda
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Iacobelli, Simona
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van Biezen, Anja
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van der Werf, Steffie
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Mikulska, Małgorzata
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Gil, Lidia
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Cordonnier, Catherine
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Ljungman, Per
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Averbuch, Diana
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Cesaro, Simone
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Cámara, Rafael de la
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Baldomero, Helen
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Bader, Peter
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Basak, Grzegorz
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Bonini, Chiara
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Duarte Palomino, Rafael
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Dufour, Carlo
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Kuball, Jurgen
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Lankester, Arjan
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Montoto, Silvia
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Nagler, Arnon
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Snowden, John A.
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Kröger, Nicolaus
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Mohty, Mohamad
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Gratwohl, Alois
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Correction: Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) (Bone Marrow Transplantation, (2020), 55, 4, (681-694), 10.1038/s41409-019-0718-7)
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