Ultra-processed food consumption is associated with renal function decline in older adults: A prospective cohort study
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
MDPI, Basel, SwitzerlandDate
2021-02-28Citation
10.3390/nu13020428
Nutrients 13.2 (2021): 428
ISSN
2072-6643DOI
10.3390/nu13020428Funded by
Data collection was funded by the following grants: FIS PI09/1626, PI16/00609, PI16/01460, PI17/1709, PI20/144 (State Secretary of R + D and FEDER/FSE), and the CIBERESP, Instituto de Salud Carlos III. Madrid, Spain. Carolina Donat-Vargas has an “Atracción de talento” contract from the Regional Government of the Madrid Community/IMDEA FoodProject
Gobierno de España. PI09/1626; Gobierno de España. PI16/00609; Gobierno de España. PI16/01460; Gobierno de España. PI17/1709; Gobierno de España. PI20/144Editor's Version
https://doi.org/10.3390/nu13020428Subjects
Creatinine serum levels; Glomerular filtration rate; Renal function decline; Ultra-processed food; MedicinaRights
© 2021 The authorsAbstract
Ultra-processed food (UPF) consumption has been associated with increased risk of cardiovascular risk factors and mortality. However, little is known on the UPF effect on renal function. The aim of this study is to assess prospectively the association between consumption of UPF and renal function decline. This is a prospective cohort study of 1312 community-dwelling individuals aged 60 and older recruited during 2008–2010 and followed up to December 2015. At baseline, a validated dietary history was obtained. UPF was identified according to NOVA classification. At baseline and at follow-up, serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) levels were ascertained and changes were calculated. A combined end-point of renal decline was considered: SCr increase or eGFR decreased beyond that expected for age. Logistic regression with adjustment for potential confounders was performed. During follow-up, 183 cases of renal function decline occurred. The fully adjusted odds ratios (95% CI) of renal function decline across terciles of percentage of total energy intake from UPF were 1.56 (1.02–2.38) for the second tercile, and 1.74 (1.14–2.66) for the highest tercile; p-trend was 0.026. High UPF consumption is independently associated with an increase higher than 50% in the risk of renal function decline in Spanish older adults.
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Google Scholar:Rey-García, Jimena
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Donat-Vargas, Carolina
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Sandoval-Insausti, Helena
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Bayan-Bravo, Ana
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Moreno-Franco, Belén
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Banegas Banegas, José Ramón
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Rodríguez Artalejo, Fernando
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Guallar Castillón, María Pilar
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