Turn on fluorescence sensing of Zn2+ based on fused isoindole-imidazole scaffold
Entity
UAM. Departamento de QuímicaPublisher
MDPIDate
2022-05-01Citation
10.3390/molecules27092859
Molecules 27.9 (2022): 2859
ISSN
1420-3049 (online)DOI
10.3390/molecules27092859Editor's Version
https://doi.org/10.3390/molecules27092859Subjects
Aluminum; Zinc Ion; Schiff Bases; QuímicaRights
© 2022 by the authorsAbstract
Optical chemosensors caused a revolution in the field of sensing due to their high specificity, sensitivity, and fast detection features. Imidazole derivatives have offered promising features in the literature as they bear suitable donor/acceptor groups for the selective analytes in the skeleton. In this work, an isoindole-imidazole containing a Schiff base chemosensor (1-{3-[(2-Diethylamino-ethylimino)-methyl]-2-hydroxy-5-methyl-phenyl}-2H-imidazo[5,1-a]isoindole-3,5-dione) was de-signed and synthesized. The complete sensing phenomena have been investigated by means of UV-Vis, fluorescence, lifetime measurement, FT-IR, NMR and ESI-MS spectroscopic techniques. The optical properties of the synthesized ligand were investigated in 3:7 HEPES buffer:DMSO medium and found to be highly selective and sensitive toward Zn2+ ion through a fluorescence turn-on response with detection limit of 0.073 µm. Furthermore, this response is effective in gel form also. The competition studies reveal that the response of the probe for Zn2+ ion is unaffected by other relevant metal ions. The stoichiometric binding study was performed utilizing Job’s method which indicated a 1:1 sensor–Zn2+ ensemble. Computational calculations were performed to pinpoint the mechanism of sensing
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Google Scholar:Sahu, Sutapa
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Sikdar, Yeasin
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Bag, Riya
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Cerezo Bastida, Javier
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Cerón-Carrasco, José P.
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Goswami, Sanchita
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