Upregulated proteasome subunits in COVID-19 patients: a link with hypoxemia, lymphopenia and inflammation
Entity
UAM. Departamento de MedicinaPublisher
MDPIDate
2022-03-13Citation
10.3390/biom12030442
Biomolecules 12.3 (2022): 442
ISSN
2218-273X (online)DOI
10.3390/biom12030442Funded by
This research was funded by Health Research Fund (Fondo de Investigación Sanitario [FIS])-European Regional Development Fund (FEDER), Spain through PI19/01612 (F.G.-R.) and COV20/00207 and PI19-01363 (C.C.-Z.) and ISCIII (CP18/00028), co-funded by ESF, “Investing in your future”Project
Gobierno de España. PI19/01612; Gobierno de España. COV20/00207; Gobierno de España. PI19-01363; Gobierno de España. CP18/00028Editor's Version
https://doi.org/10.3390/biom12030442Subjects
COVID-19; Hyperinflammation; Hypoxemia; Lymphopenia; Proteasome subunits; MedicinaRights
© 2022 by the authorsAbstract
Severe COVID-19 disease leads to hypoxemia, inflammation and lymphopenia. Viral infection induces cellular stress and causes the activation of the innate immune response. The ubiquitin-proteasome system (UPS) is highly implicated in viral immune response regulation. The main function of the proteasome is protein degradation in its active form, which recognises and binds to ubiquitylated proteins. Some proteasome subunits have been reported to be upregulated under hypoxic and hyperinflammatory conditions. Here, we conducted a prospective cohort study of COVID-19 patients (n = 44) and age-and sex-matched controls (n = 20). In this study, we suggested that hypoxia could induce the overexpression of certain genes encoding for subunits from the α and β core of the 20S proteasome and from regulatory particles (19S and 11S) in COVID-19 patients. Furthermore, the gene expression of proteasome subunits was associated with lymphocyte count reduction and positively correlated with inflammatory molecular and clinical markers. Given the importance of the proteasome in maintaining cellular homeostasis, including the regulation of the apoptotic and pyroptotic pathways, these results provide a potential link between COVID-19 complications and proteasome gene expression
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Artículo principal
Google Scholar:Alfaro, Enrique
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Díaz García, Elena
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García‑Tovar, Sara
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Zamarrón, Ester
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Mangas, Alberto
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Galera, Raúl
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López-Collazo, Eduardo
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García Rio, Francisco
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Cubillos-Zapata, Carolina
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