Antibacterial films of silver nanoparticles embedded into carboxymethylcellulose/chitosan multilayers on nanoporous silicon: A layer-by-layer assembly approach comparing dip and spin coating
Entity
UAM. Departamento de Física AplicadaPublisher
MDPIDate
2023-07-01Citation
10.3390/ijms241310595
International Journal of Molecular Sciences 24.13 (2023): 10595
ISSN
1661-6596 (print); 1422-0067 (online)DOI
10.3390/ijms241310595Funded by
PID2020-112770RB-C22Project
Gobierno de España. PID2020-112770RB-C22Editor's Version
https://doi.org/10.3390/ijms241310595Subjects
Bacterial Adhesion; Metal Nanoparticles; Silicon; Silver; FísicaRights
© 2023 by the authorsAbstract
The design and engineering of antibacterial materials are key for preventing bacterial adherence and proliferation in biomedical and household instruments. Silver nanoparticles (AgNPs) and chitosan (CHI) are broad-spectrum antibacterial materials with different properties whose combined application is currently under optimization. This study proposes the formation of antibacterial films with AgNPs embedded in carboxymethylcellulose/chitosan multilayers by the layer-by-layer (LbL) method. The films were deposited onto nanoporous silicon (nPSi), an ideal platform for bioengineering applications due to its biocompatibility, biodegradability, and bioresorbability. We focused on two alternative multilayer deposition processes: cyclic dip coating (CDC) and cyclic spin coating (CSC). The physicochemical properties of the films were the subject of microscopic, microstructural, and surface–interface analyses. The antibacterial activity of each film was investigated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria strains as model microorganisms. According to the findings, the CDC technique produced multilayer films with higher antibacterial activity for both bacteria compared to the CSC method. Bacteria adhesion inhibition was observed from only three cycles. The developed AgNPs–multilayer composite film offers advantageous antibacterial properties for biomedical applications
Files in this item
Google Scholar:Naveas, Nelson
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Pulido, Ruth
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Torres Costa, Vicente
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Agulló-Rueda, Fernando
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Santibáñez, Mauricio
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Malano, Francisco
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Recio-Sánchez, Gonzalo
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Garrido-Miranda, Karla A.
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Manso Silván, Miguel
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Hernández-Montelongo, Jacobo
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