Development of a prediction model for short-term remission of patients with crohn’s disease treated with Anti-TNF drugs
Author
Medina Medina, Rosario; Iglesias-Flores, Eva; Benítez, Jose M.; Marín-Pedrosa, Sandra; Salgueiro-Rodríguez, Isabel; Linares, Clara I.; González-Rubio, Sandra; Soto-Escribano, Pilar; Gros, Beatriz; Rodríguez-Perálvarez, Manuel L.; Cabriada, José L.; Chaparro Sánchez, María; Pérez Gisbert, Francisco Javier; Chicano-Gálvez, Eduardo; Ortea, Ignacio; Ferrín, Gustavo; García-Sánchez, Valle; Aguilar-Melero, PatriciaEntity
UAM. Departamento de MedicinaPublisher
MDPIDate
2023-05-12Citation
10.3390/ijms24108695
International Journal of Molecular Sciences 24.10 (2023): 8695
ISSN
1422-0067 (online); 1661-6596 (print)DOI
10.3390/ijms24108695Funded by
This research was supported by the “Plan Nacional de I + D + I Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII), Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER)” (grant number PI15/01352). R.M-M. was supported by Consejería de Salud y Familias, Junta de Andalucía (PI-0199-2013). G.F. was supported by CIBEREHD (Instituto de Salud Carlos III)Project
Gobierno de España. PI15/01352Editor's Version
https://doi.org/10.3390/ijms24108695Subjects
inflammatory bowel disease; crohn’s disease; SWATH proteomics; predictive biomarkers; anti-TNF-a therapy; vinculin; MedicinaRights
© 2023 by the authorsAbstract
Therapy with anti-tumor necrosis factor (TNF) has dramatically changed the natural history
of Crohn’s disease (CD). However, these drugs are not without adverse events, and up to 40% of
patients could lose efficacy in the long term. We aimed to identify reliable markers of response to
anti-TNF drugs in patients with CD. A consecutive cohort of 113 anti-TNF naive patients with CD was
stratified according to clinical response as short-term remission (STR) or non-STR (NSTR) at 12 weeks
of treatment. We compared the protein expression profiles of plasma samples in a subset of patients
from both groups prior to anti-TNF therapy by SWATH proteomics. We identified 18 differentially
expressed proteins (p ≤ 0.01, fold change ≥ 2.4) involved in the organization of the cytoskeleton
and cell junction, hemostasis/platelet function, carbohydrate metabolism, and immune response
as candidate biomarkers of STR. Among them, vinculin was one of the most deregulated proteins
(p < 0.001), whose differential expression was confirmed by ELISA (p = 0.054). In the multivariate
analysis, plasma vinculin levels along with basal CD Activity Index, corticosteroids induction, and
bowel resection were factors predicting NSTR
Files in this item
Google Scholar:Medina Medina, Rosario
-
Iglesias-Flores, Eva
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Benítez, Jose M.
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Marín-Pedrosa, Sandra
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Salgueiro-Rodríguez, Isabel
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Linares, Clara I.
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González-Rubio, Sandra
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Soto-Escribano, Pilar
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Gros, Beatriz
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Rodríguez-Perálvarez, Manuel L.
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Cabriada, José L.
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Chaparro Sánchez, María
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Pérez Gisbert, Francisco Javier
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Chicano-Gálvez, Eduardo
-
Ortea, Ignacio
-
Ferrín, Gustavo
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García-Sánchez, Valle
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Aguilar-Melero, Patricia
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