Clinico-pathological features, outcomes and impacts of COVID-19 pandemic on patients with early-onset colorectal cancer: A single-Institution Experience
Entity
UAM. Departamento de Anatomía, Histología y Neurociencia; UAM. Departamento de Bioquímica; UAM. Departamento de MedicinaPublisher
MDPIDate
2023-08-24Citation
10.3390/cancers15174242
Cancers 15.17 (2023): 4242
ISSN
2072-6694 (online)DOI
10.3390/cancers15174242Funded by
The work in the authors’ laboratory is funded by the Instituto de Salud Carlos III (ISCIII) and the Fondo Europeo de Desarrollo Regional (FEDER) (ICI20/00057, CIBERONC/CB16/12/00273, and CIBERONC/CB16/12/00398), as well as the Comunidad de Madrid (S2022/BMD-7212)Project
Gobierno de España. ICI20/00057; Gobierno de España. CB16/12/00273; Gobierno de España. CB16/12/00398; Comunidad de Madrid. 2022/BMD-7212Editor's Version
https://doi.org/10.3390/cancers15174242Subjects
early-onset colorectal cancer; COVID-19 pandemic; prognosis; MedicinaRights
© 2023 by the authorsAbstract
The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC), as well as the impacts of COVID-19 pandemic. Methods: We included all patients with pathologically confirmed diagnoses of CRC at Hospital Universitario La Paz from October 2016 to December 2021. The EOCRC cut-off age was 50 years old. Results: A total of 1475 patients diagnosed with CRC were included, eighty (5.4%) of whom had EOCRC. Significant differences were found between EOCRC and later-onset patients regarding T, N stage and metastatic presentation at diagnosis; perineural invasion; tumor budding; high-grade tumors; and signet ring cell histology, with all issues having higher prevalence in the early-onset group. More EOCRC patients had the RAS/ BRAF wild type. Chemotherapy was administered more frequently to patients with EOCRC. In the metastatic setting, the EOCRC group presented a significantly longer median OS. Regarding the COVID-19 pandemic, more patients with COVID-19 were diagnosed with metastatic disease (61%) in the year after the lockdown (14 March 2020) than in the pre-pandemic EOCRC group (29%). Conclusions: EOCRC is diagnosed at a more advanced stage and with worse survival features in localized patients. More patients with EOCRC were diagnosed with metastatic disease in the year after the COVID-19 pandemic lockdown. The long-term consequences of COVID-19 are yet to be determined
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Google Scholar:Martínez-Pérez, Daniel
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Prieto Nieto, María Isabel
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González Sancho, José Manuel
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Feliú Batlle, Jaime
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Rodríguez Salas, Nuria
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