Early in vivo detection of denervation-induced atrophy by luminescence transient nanothermometry
Author
Lifante Cañavate, José; Moreno Rupérez, Álvaro; Ximendes, Erving Clayton; Marin, Riccardo; Priego, Teresa; López Calderón, Asunción; Martín, Ana Isabel; Nieto Bona, María Paz; Nebot, Elena; Lifante Pedrola, Ginés; Jaque García, Daniel; Monge Sánchez, Luis; Fernández Monsalve, Nuria; Granado García, MiriamEntity
UAM. Departamento de Física de Materiales; UAM. Departamento de FisiologíaPublisher
WileyDate
2023-11-17Citation
10.1002/jbio.202300249
Journal of Biophotonics (2023): e202300249
ISSN
1864-063X (print); 1864-0648 (online)DOI
10.1002/jbio.202300249Funded by
Comunidad de Madrid, Grant/Award Number: S2017/BMD-3867 RENIM-CM; COST action CA17140 (Nano2Clinic); European Structural and Investment Fund and the Ministerio de Economía y Competitividad-MINECO, Grant/Award Number: PID2019-106211RB-I00; Juan de la Cierva scholarship, Grant/Award Number: IJC2020-045229-IProject
Gobierno de España. PID2019-106211RB-I00Editor's Version
https://doi.org/10.1002/jbio.202300249Subjects
Denervation; Infrared-emitting nanoparticles; Luminescent nanothermometers; Muscle atrophy; Transient thermometry; Física; MedicinaRights
© 2023 The AuthorsAbstract
Denervation induces skeletal muscle
atrophy due to the loss of control and
feedback with the nervous system. Unfortunately, muscle atrophy only becomes
evident days after the denervation event
when it could be irreversible. Alternative
diagnosis tools for early detection of
denervation-induced muscle atrophy are,
thus, required. In this work, we demonstrate how the combination of transient thermometry, a technique already
used for early diagnosis of tumors, and infrared-emitting nanothermometers
makes possible the in vivo detection of the onset of muscle atrophy at short
(<1 day) times after a denervation event. The physiological reasons behind
these experimental results have been explored by performing three dimensional numerical simulations based on the Pennes' bioheat equation. It is concluded that the alterations in muscle thermal dynamics at the onset of muscle
atrophy are consequence of the skin perfusion increment caused by the
alteration of peripheral nervous autonomous system. This work demonstrates
the potential of infrared luminescence thermometry for early detection of diseases of the nervous system opening the venue toward the development of new
diagnosis tools
Files in this item
Google Scholar:Lifante Cañavate, José
-
Moreno Rupérez, Álvaro
-
Ximendes, Erving Clayton
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Marin, Riccardo
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Priego, Teresa
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López Calderón, Asunción
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Martín, Ana Isabel
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Nieto Bona, María Paz
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Nebot, Elena
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Lifante Pedrola, Ginés
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Jaque García, Daniel
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Monge Sánchez, Luis
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Fernández Monsalve, Nuria
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Granado García, Miriam
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