High consumption of ultra-processed food may double the risk of subclinical coronary atherosclerosis: The Aragon Workers' Health Study (AWHS)
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y MicrobiologíaPublisher
BioMed CentralDate
2020-08-13Citation
10.1186/s12916-020-01678-8
BMC Medicine 18.1 (2020): 235
ISSN
1741-7015 (online)DOI
10.1186/s12916-020-01678-8Funded by
AWHS was funded through a collaboration agreement between the Aragonese Institute of Health Sciences (I+CS) of the Regional Government of Aragon, the National Cardiovascular Research Centre (CNIC) of the Carlos III Health Institute, and Opel Spain. This study was also partially supported by grants: PI17/1709 (Secretary of State for R&D and ERDF/ESF), and Integrated Projects of Excellence in Health Research Institutes PIE16/00022 (Secretary of State for R&D and ERDF/ESF), the ATHLOS Project (EU H2020-ID project: 635316), CIBERCV and CIBERESP of the Carlos III Health Institute, Madrid, SpainProject
Gobierno de España. PI17/1709; Gobierno de España. PIE16/00022; info:eu-repo/grantAgreement/EC/H2020/635316/EU//ATHLOSEditor's Version
https://doi.org/10.1186/s12916-020-01678-8Subjects
coronary calcium; cross-sectional cohort study; nutritional epidemiology; subclinical coronary atherosclerosis; ultra-processed food; MedicinaRights
© 2020 The Author(s)Abstract
Background: Ultra-processed food (UPF) consumption, which is increasing worldwide, has recently been associated with an increased risk of death and cardiovascular disease. We aimed to assess whether consumption of UPF is directly associated with subclinical coronary atherosclerosis in middle-aged men. Methods: A computed tomography scan was performed on 1876 men from the Aragon Workers' Health Study, recruited from January 2011 to December 2014, to assess coronary calcium. All participants were free of coronary heart disease. Dietary intake was collected by a validated 136-item semi-quantitative food frequency questionnaire. UPF was defined according to the NOVA classification. Associations between consumption of total energy-adjusted UPF and Coronary Calcium Agatston Score (CACS) - categorized into CACS of 0, > 0 and < 100, and ≥ 100 - were cross-sectionally assessed by generalized ordered logistic regression adjusted for main confounders. Results: No coronary calcium was detected in 60.2% of the participants, whereas 10.2% had a CACS ≥ 100. A significant dose-response association was observed between energy-adjusted UPF consumption and the risk of having a CACS ≥ 100, when compared with those in the lowest CACS categories (CACS of 0 together with CACS > 0 and < 100). The fully adjusted ORs (95% CI) of having a CACS ≥ 100 across quartiles of energy-adjusted UPF consumption (approximately 100 g/day in the lowest quartile (ref.) and 500 g/day in the highest) were 1.00 (ref.), 1.50 (0.93, 2.42), 1.56 (0.96, 2.52), and 2.00 (1.26, 3.16), p trend.005. Conclusion: In this middle-aged worker's sample, approximately 500 g/day of UPF consumption was associated with a 2-fold greater prevalence of subclinical coronary atherosclerosis than consuming only 100 g/day, independently of total energy intake and other well-established cardiovascular risk factors
Files in this item
Google Scholar:Montero-Salazar, Henry
-
Donat-Vargas, Carolina
-
Moreno-Franco, Belén
-
Sandoval Insausti, Helena
-
Civeira, Fernando
-
Laclaustra, Martín
-
Guallar Castillón, María Pilar
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke
Donat-Vargas, Carolina; Sandoval-Insausti, Helena; Peñalvo, José L.; Moreno Iribas, Maria Concepción; Amiano, Pilar; Bes-Rastrollo, Maira; Molina-Montes, Esther; Moreno-Franco, Belén; Agudo, Antonio; Mayo, Cristina Lasheras; Laclaustra, Martín; De La Fuente Arrillaga, Carmen; Chirlaque Lopez, Maria Dolores; Sánchez, Maria José; Martínez-Gonzalez, Miguel Angel; Pilar, Guallar Castillón
2021-12-03