Leptin concentration, obesity, and plasma non-esterified fatty acid levels in children
Entity
UAM. Departamento de PediatríaPublisher
Frontiers MediaDate
2022-01-06Citation
10.3389/fped.2021.812779
Frontiers in Pediatrics 9 (2022): 812779
ISSN
2296-2360 (online)DOI
10.3389/fped.2021.812779Funded by
This work was supported by the Instituto de Salud Carlos III (grants number PI 18/01016 and FI 19/00180) and Biobank (grant number FEDER RD09/0076/00101). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptProject
Gobierno de España. PI18/01016; Gobierno de España. FI19/00180; Gobierno de España. RD09/0076/00101Editor's Version
https://doi.org/10.3389/fped.2021.812779Subjects
non-esterified fatty acids; leptin; obesity; BMI; children; MedicinaRights
© 2022 Vales-Villamarín, Ortega-Senovilla, Dios, Pérez-Nadador, GavelaPérez, Soriano-Guillén and GarcésAbstract
The association between obesity and higher non-esterified fatty acid (NEFA) levels has been established in adults. In contrast, lower NEFA levels have been described in children with obesity although the reason behind this association remains unclear. Leptin, which regulates body weight and plays a role in lipolysis, could be involved in this relationship. We evaluated the influence of leptin in the association between obesity and NEFA concentrations in children, analyzing two cohorts including 684 6- to 8-year-olds and 836 12- to 16-year-old children, respectively. After adjusting by leptin, insulin levels remained significantly higher in adolescents with obesity as compared with levels in those without obesity. However, insulin levels showed no differences between prepubertal children with and without obesity. The significantly lower NEFA concentrations observed in 6- to 8-year-old girls with obesity disappeared when comparing NEFA levels between girls with and without obesity after adjusting by leptin. We report an influence of leptin levels on the association between obesity and insulin and NEFA in young children that is not observed in adolescents. Our findings add information about factors that may contribute to explain the lower NEFA levels described in prepubertal children with obesity
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Google Scholar:Vales-Villamarín, Claudia
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Ortega Senovilla, Henar
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De Dios, Olaya
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Pérez-Nadador, Iris
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Gavela Pérez, Teresa
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Soriano Guillén, Leandro
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Garcés, Carmen
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