Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB 5-6 lineage

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dc.contributor.author Losada-Pérez, María
dc.contributor.author Gabilondo, Hugo
dc.contributor.author Molina, Isabel
dc.contributor.author Turiegano, Enrique
dc.contributor.author Torroja, Laura
dc.contributor.author Thor, Stefan
dc.contributor.author Benito-Sipos, Jonathan
dc.contributor.other UAM. Departamento de Biología es_ES
dc.date.accessioned 2014-05-30T08:10:59Z
dc.date.available 2014-05-30T08:10:59Z
dc.date.issued 2013
dc.identifier.citation Development 140.10 (2013): 2181-2189 es_ES
dc.identifier.issn 0950-1991 (print) es_ES
dc.identifier.issn 1477-9129 (online) es_ES
dc.identifier.uri http://hdl.handle.net/10486/660449
dc.description.abstract A number of transcription factors that are expressed within most, if not all, embryonic neuroblast (NB) lineages participate in neural subtype specification. Some have been extensively studied in several NB lineages (e.g. components of the temporal gene cascade) whereas others only within specific NB lineages. To what extent they function in other lineages remains unknown. Klumpfuss (Klu), the Drosophilaortholog of the mammalian Wilms tumor 1 (WT1) protein, is one such transcription factor. Studies in the NB4-2 lineage have suggested that Klu functions to ensure that the two ganglion mother cells (GMCs) in this embryonic NB lineage acquire different fates. Owing to limited lineage marker availability, these observations were made only for the NB4-2 lineage. Recent findings reveal that Klu is necessary for larval neuroblast growth and self-renewal. We have extended the study of Klu to the well-known embryonic NB5-6T lineage and describe a novel role for Klu in the Drosophila embryonic CNS. Our results demonstrate that Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling. Our findings indicate a pleiotropic function of Klu in Ap cluster specification in general and particularly in Ap4 neuron differentiation, indicating that Klu is a multitasking transcription factor. Finally, our studies indicate that a transitory downregulation of klu is crucial for the specification of the Ap4/FMRFa neuron. Similar to WT1, kluseems to have either self-renewal or differentiation-promoting functions, depending on the developmental context en_US
dc.format.extent 28 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso eng es_ES
dc.publisher The Company of Biologist Ltd. en_US
dc.relation.ispartof Development en_US
dc.subject.other Drosophila en_US
dc.subject.other Klumpfuss en_US
dc.subject.other Terminal differentiation en_US
dc.subject.other BMP signaling en_US
dc.subject.other Neuropeptidergic cell identity en_US
dc.subject.other FMRFa es_ES
dc.title Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB 5-6 lineage en_US
dc.type article en
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion http://dx.doi.org/10.1242/dev.089748
dc.identifier.doi 10.1242/dev.089748 es_ES
dc.identifier.publicationfirstpage 2181 es_ES
dc.identifier.publicationissue 140 es_ES
dc.identifier.publicationlastpage 2189 es_ES
dc.identifier.publicationvolume 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.rights.accessRights openAccess es_ES
dc.authorUAM Losada Pérez, María (261918)
dc.authorUAM Torroja Fungairiño, Laura (260046)


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