Bisphenol A in chronic kidney disease
Entity
UAM. Departamento de MedicinaPublisher
HindawiDate
2013-09-23Citation
10.1155/2013/437857
International Journal of Nephrology 2013 (2013): 437857
ISSN
2090-214XDOI
10.1155/2013/437857Funded by
This research was supported by a grant from ISCIII and FEDER funds PS09/00447, Sociedad Española de Nefrologia, ISCIII-RETICREDinREN/RD06/0016, RD12/0021/,Comunidad de Madrid/CIFRA/S2010/BMD-2378, and salary support was from ERA/EDTA to Usama Elewa and Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to Alberto Ortiz Arduán. ISC III (PI10/ 00072), RECAVA (RD06/0014/0038) and Lilly Foundation to Jesús Egido.Project
Comunidad de Madrid. S2010/BMD-2378/CIFRAEditor's Version
http://dx.doi.org/10.1155/2013/437857Subjects
Kidney; Bisphenol A; MedicinaRights
© 2013 Emilio González-Parra et al.Abstract
Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some dialyzers. BPA is considered an environmental toxicant based on animal and cell culture studies. Japanese authorities recently banned BPA use in baby bottles based on observational association studies in newborns. BPA is excreted in urine and uremic patients present higher serum levels, but there is insufficient evidence to set cut-off levels or to link BPA to any harmful effect in CKD. However, the renal elimination and potential exposure during dialysis warrant the monitoring of BPA exposure and the design of observational studies in which the potential health risks of BPA for end-stage renal disease patients are evaluated.
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Google Scholar:González-Parra, Emilio
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Herrero, José Antonio
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Elewa, Usama
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Bosch, Ricardo J.
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Ortiz Arduán, Alberto
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Egido, Jesús
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